Hexirest 5 mg (Tablet)
Unit Price: ৳ 12.00 (3 x 10: ৳ 360.00)
Strip Price: ৳ 120.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Trihexyphenidyl hydrochloride |
| Company | Everest pharmaceuticals ltd |
| Also available as |
Title
Hexirest Antiparkinson Drug
Categories
- antiparkinson
- neurological disorders
- central nervous system drugs
- muscarinic acetylcholine receptor antagonist
- anticholinergic
- dopamine release modifier
Description
Hexirest is indicated as an adjunct treatment for parkinsonism and extrapyramidal disorders caused by central nervous system drugs.
Pharmacology
- non-selective muscarinic acetylcholine receptor antagonist
- higher affinity for central muscarinic receptors
- dopamine release modifier
- mechanism of action not fully elucidated
DosageAdministration
- individualized dosage
- low initial dose, increased gradually
- optimal dose dependent on patient's reaction
- therapy for idiopathic parkinsonism
- therapy for drug-induced parkinsonism
- concomitant use with levodopa
- ease of administration before or after meals
- dosage adjustment for children
Interaction
- additive effects with cannabinoids, barbiturates, opiates, and alcohol
- possible increased sedative effects with CNS depressants
- intensified anticholinergic effects with MAO inhibitors and tricyclic antidepressants
- increased risk of tardive dyskinesia with concomitant use of anticholinergics and neuroleptics
- possible need for reduced dose of levodopa during concomitant therapy
Contraindications
Hypersensitivity to Trihexyphenidyl, narrow angle glaucoma
SideEffects
- dryness of the mouth
- blurred vision
- dizziness
- nausea
- nervousness
- suppurative parotitis
- skin rashes
- dilatation of the colon
- paralytic ileus
- psychiatric manifestations
- cognitive dysfunctions
- constipation
- drowsiness
- urinary hesitancy or retention
- tachycardia
- dilation of the pupil
- increased intraocular pressure
- choreiform movements
- weakness
- vomiting
- headache
- exacerbation of parkinsonism with abrupt withdrawal
- Neuroleptic malignant syndrome with abrupt withdrawal
- angle-closure glaucoma
- sinus bradycardia
- dry skin
- cycloplegia
- adverse events in pediatric patients
PregnancyLactation
- No controlled data in animal or human pregnancy
- Use only if benefit outweighs risk
- Potential risk to infant during lactation
PrecautionsWarnings
- Gonioscope evaluation prior to therapy
- Monitoring of intraocular pressures
- Caution in hot weather
- Caution with other atropine-like drugs
- Risk of anhidrosis and hyperthermia
- Neuroleptic Malignant Syndrome
OverdoseEffects
- Rare cases of death associated with Hexirest overdoses
- Central anticholinergic syndrome
- Symptomatic and supportive therapy for acute overdose
- Gastric lavage for limiting absorption
- Administration of diazepam or short-acting barbiturate for CNS excitation
- Contraindication of phenothiazines
- Respiratory support, artificial respiration, vasopressor agents may be necessary
TherapeuticClass
Antiparkinson drugs
StorageConditions
Store at temperature not exceeding 30° C in a dry place, protect from light