Lopirel Plus 75 mg+75 mg (Tablet)
Unit Price: ৳ 12.00 (3 x 10: ৳ 360.00)
Strip Price: ৳ 120.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Clopidogrel aspirin |
| Company | Incepta pharmaceuticals ltd |
Product Title
- Lopirel Plus
Categories
- Medicine
- Pharmaceutical
Description
- Lopirel Plus is indicated to reduce the rate of Myocardial Infarction (MI) and Stroke in patients with non-ST-segment elevation ACS and acute ST-segment elevation ACS.
Color Options
- Not applicable
Dimensions
- Not applicable
Functions
- Reduces the rate of Myocardial Infarction (MI) and Stroke
- Inhibits platelet activation and aggregation
Materials
- Clopidogrel
- Aspirin
Technical Specifications
- Clopidogrel: Irreversibly binds to the P2Y12 class of ADP receptors on platelets
- Inhibition of platelet aggregation seen at 2 hours after single oral doses
- Aspirin: Irreversible inhibition of platelet cyclooxygenase
Design Elements
- Prodrug
Usability Features
- Recommended dose of 75 mg once daily with or without food
- No dosage adjustment for elderly patients or patients with renal impairment
Dosage & Administration
- Recommended dose: 75 mg once daily with or without food
- Initiation with a single 300 mg loading dose for patients with acute coronary syndrome (unstable angina/non-Q-wave MI)
- Combination with Aspirin (75 mg-325 mg once daily)
Interaction
- No modification by Aspirin of the Clopidogrel-mediated inhibition of ADP-induced platelet aggregation
- Concomitant administration with NSAIDs associated with increased occult gastrointestinal blood loss
- Caution with concomitant administration of Warfarin
Contraindications
- Hypersensitivity to the drug substance or any component
- Active pathological bleeding such as peptic ulcer or intracranial hemorrhage
Side Effects
- Generally well tolerated
Pregnancy & Lactation
- Use during first and second trimesters of pregnancy only if clearly needed
- Contraindicated during the third trimester of pregnancy
- Discontinuation during breastfeeding
Precautions & Warnings
- May prolong bleeding time
- Rare reports of Thrombotic thrombocytopenic purpura (TTP)
- Potential development of Reye's syndrome
Use in Special Populations
- Not recommended for children, particularly those under 12 years
- Aspirin may be a contributory factor in the causation of Reye's syndrome in some children
Overdose Effects
- Clopidogrel overdose may lead to bleeding complications
- Moderate Aspirin intoxication symptoms include dizziness, headache, tinnitus, confusion, and gastrointestinal symptoms
- Severe Aspirin intoxication may lead to respiratory and metabolic issues
Therapeutic Class
- Anti-platelet drugs
Storage Conditions
- Keep in a cool & dry place (below 30°C)
- Protected from light & moisture
- Keep out of the reach of children