Tribcol 5 mg (Tablet)
Unit Price: ৳ 12.00 (3 x 10: ৳ 360.00)
Strip Price: ৳ 120.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Trihexyphenidyl hydrochloride |
| Company | Genvio pharma ltd |
| Also available as |
Indications
- Adjunct in the treatment of parkinsonism
- Useful as adjuvant therapy with levodopa
- Control of extrapyramidal disorders
Description
- Exerts inhibitory effect on parasympathetic nervous system
- Relaxing effect on smooth musculature
Pharmacology
- Non-selective muscarinic acetylcholine receptor antagonist
- Binds with higher affinity to M1 subtype
- Higher affinity for central muscarinic receptors in cerebral cortex
- May modify nicotinic acetylcholine receptor neurotransmission
Dosage & Administration
- Individualized dosage
- Low initial dose, gradual increase, especially in elderly patients
- May be given before or after meals
- Abrupt withdrawal may result in acute exacerbation of symptoms
- May be used concomitantly with levodopa or other parasympathetic inhibitors
Interaction
- Additive effects with cannabinoids, barbiturates, opiates, and alcohol
- Increased sedative effects with alcohol or other CNS depressants
- Increased risk for tardive dyskinesia with neuroleptics
- Possible need to reduce dosage of levodopa during concomitant therapy
Contraindications
- Hypersensitivity to Trihexyphenidyl
- Narrow angle glaucoma
Side Effects
- Dryness of the mouth
- Blurred vision
- Dizziness
- Nausea
- Nervousness
- Suppurative parotitis
- Skin rashes
- Delusions
- Hallucinations
- Paranoia
- Cognitive dysfunctions
- Constipation
- Drowsiness
- Urinary hesitancy or retention
- Tachycardia
- Dilation of the pupil
- Increased intraocular pressure
- Choreiform movements
- Weakness
- Vomiting
- Headache
Pregnancy & Lactation
- Limited data in pregnancy
- Recommended only if benefit outweighs risk
- Caution in nursing women
Precautions & Warnings
- Gonioscope evaluation prior to therapy
- Monitoring of intraocular pressures
- Caution in hot weather, especially with concomitant use of other anticholinergics
- Risk of hyperthermia with anhidrosis
- Potential for Neuroleptic Malignant Syndrome
Overdose Effects
- Central symptoms of atropine intoxication
- Neuropsychiatric signs such as delirium, disorientation, seizures
- Treatment involves symptomatic and supportive therapy
Therapeutic Class
- Antiparkinson drugs
Storage Conditions
- Store at temperature not exceeding 30°C
- Protect from light