Tribcol 2 mg (Tablet)
Unit Price: ৳ 5.00 (3 x 10: ৳ 150.00)
Strip Price: ৳ 50.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Trihexyphenidyl hydrochloride |
| Company | Genvio pharma ltd |
| Also available as |
Indications
- Adjunct in the treatment of all forms of parkinsonism
- Adjuvant therapy for Parkinsonism with levodopa
- Control of extrapyramidal disorders caused by central nervous system drugs
Description
- Exerts a direct inhibitory effect upon the parasympathetic nervous system
- Relaxing effect on smooth musculature
Pharmacology
- Non-selective muscarinic acetylcholine receptor antagonist
- Higher affinity for central muscarinic receptors located in the cerebral cortex
- Lower affinity for peripheral muscarinic receptors
Dosage & Administration
- Individualized dosage
- Low initial dose with gradual increase
- Appropriate timing with meals
- Abrupt withdrawal may result in acute exacerbation of symptoms
- Dosage adjustment when used concomitantly with other drugs
Interaction
- Additive effects with cannabinoids, barbiturates, opiates, and alcohol
- Increased sedative effects with concurrent use of alcohol or other CNS depressants
- Increased risk for tardive dyskinesia with concomitant administration of neuroleptics
- Need for dosage reduction when used concomitantly with monoamine oxidase inhibitors or tricyclic antidepressants
Contraindications
- Hypersensitivity to Trihexyphenidyl
- Narrow angle glaucoma
Side Effects
- Dryness of the mouth
- Blurred vision
- Dizziness
- Nausea
- Nervousness
- Excessive salivation
- Skin rashes
- Colonic dilatation
- Paralytic ileus
- Psychiatric manifestations
- Cognitive dysfunctions
- Constipation
- Drowsiness
- Urinary hesitancy or retention
- Tachycardia
- Dilation of the pupil
- Increased intraocular pressure
- Choreiform movements
- Weakness
- Vomiting
- Headache
- Exacerbation of parkinsonism with abrupt treatment withdrawal
- Neuroleptic malignant syndrome
Pregnancy & Lactation
- Use during pregnancy when benefit outweighs risk
- Caution in nursing women due to potential excretion in human milk
- Possible suppression of lactation
Precautions & Warnings
- Gonioscope evaluation and monitoring of intraocular pressures
- Risk of angle closure and increased intraocular pressure
- Caution in hot weather and in certain patient populations
- Potential occurrence of high anhidrosis and hyperthermia
- Neuroleptic Malignant Syndrome
Overdose Effects
- Typical central symptoms of atropine intoxication
- Neuropsychiatric signs such as delirium, anxiety, hallucinations
- Coma, paralysis, cardiac and respiratory arrest
- Gastric lavage for limiting absorption
- Supportive therapy for symptomatic treatment
Therapeutic Class
- Antiparkinson drugs
Storage Conditions
- Store at temperature not exceeding 30°C in a dry place
- Protect from light