Heximax 2 mg (Tablet)
Unit Price: ৳ 5.00 (3 x 10: ৳ 150.00)
Strip Price: ৳ 50.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Trihexyphenidyl hydrochloride |
| Company | Goodman pharmaceuticals ltd |
| Also available as |
Indications
- Adjunct in the treatment of parkinsonism
- Adjuvant therapy with levodopa
- Control of extrapyramidal disorders
Description
- Exerts inhibitory effect on parasympathetic nervous system
- Relaxing effect on smooth musculature
Pharmacology
- Non-selective muscarinic acetylcholine receptor antagonist
- Binds with higher affinity to M1 subtype
- Higher affinity for central muscarinic receptors in cerebral cortex
Dosage & Administration
- Individualized dosage
- Low initial dose
- Increased gradually, especially in patients over 60 years
- May be taken before or after meals
- Abrupt withdrawal may result in acute exacerbation of Parkinsonism symptoms
- Dosage adjustments for different forms of parkinsonism
Interaction
- Additive effects with cannabinoids, barbiturates, opiates, and alcohol
- Increased sedative effects with alcohol or other CNS depressants
- Intensified anticholinergic effects with monoamine oxidase inhibitors and tricyclic antidepressants
- Increased risk for tardive dyskinesia during concomitant administration of anticholinergics and neuroleptics
Contraindications
- Hypersensitivity to Trihexyphenidyl
- Narrow angle glaucoma
Side Effects
- Dryness of the mouth
- Blurred vision
- Dizziness
- Mild nausea or nervousness
- Suppurative parotitis
- Skin rashes
- Dilatation of the colon
- Paralytic ileus
- Psychiatric manifestations
- Cognitive dysfunctions
- Constipation
- Drowsiness
- Urinary hesitancy or retention
- Tachycardia
- Dilation of the pupil
- Increased intraocular pressure
- Choreiform movements
- Weakness
- Vomiting
- Headache
Pregnancy & Lactation
- Recommended for use during pregnancy only when there is a clear need and benefits outweigh risks
- Excretion in human milk
- Potential suppression of lactation
Precautions & Warnings
- Gonioscope evaluation prior to initiation of therapy
- Close monitoring of intraocular pressures
- Caution in hot weather
- Consideration of narrow angle glaucoma if blurring of vision occurs
- Possible hyperthermia with anhidrosis
- Severe anhidrosis and fatal hyperthermia under certain conditions
Overdose Effects
- Typical central symptoms of atropine intoxication
- Neuropsychiatric signs
- Progression to stupor, coma, paralysis, cardiac and respiratory arrest, and death
- Symptomatic and supportive therapy for acute overdose
- Gastric lavage or other methods to limit absorption
- Respiratory support, artificial respiration, or vasopressor agents
Therapeutic Class
Antiparkinson drugs
Storage Conditions
- Store at temperature not exceeding 30°C
- Dry place
- Protect from light