Origolix 200 mg (Tablet)
Unit Price: ৳ 235.00 (1 x 10: ৳ 2,350.00)
Strip Price: ৳ 2,350.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Elagolix sodium |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Management of moderate to severe pain associated with endometriosis
Pharmacology
- GnRH receptor antagonist
- Inhibition of endogenous GnRH signaling
- Competitive binding to GnRH receptors
- Suppression of luteinizing hormone (LH) and follicle-stimulating hormone (FSH)
- Decreased blood concentrations of estradiol and progesterone
Dosage & Administration
- Initial treatment with Elagolix 150 mg
- Initial treatment with Elagolix 200 mg
- Use in moderate to severe hepatic impairment
- Use in children and adolescents
- Exclusion of pregnancy before starting treatment
- Start within 7 days from the onset of menses
Interaction
- Potentiation of P-gp substrates
- Antagonism of CYP3A substrates
- Antagonism of oral midazolam and rosuvastatin
- Antagonism by CYP3A inducers
- Reduced efficacy with estrogen-containing contraceptives
Contraindications
- Pregnancy
- Known osteoporosis
- Severe hepatic impairment
- Concomitant use of strong organic anion transporting polypeptide OATP1B1 inhibitors
Side Effects
- Hot flushes
- Night sweats
- Headache
- Nausea
- Amenorrhea
- Arthralgia
- Mood changes
- Bone loss
- Insomnia
- Anxiety
- Elevated hepatic transaminase
Pregnancy & Lactation
- Contraindication in pregnant women
- Discontinuation if pregnancy occurs
- Limited human data
- No information on presence in human milk or effects on the breastfed child
Precautions & Warnings
- Bone Loss
- Reduced Ability to Recognize Pregnancy
- Suicidal Ideation and Mood Disorders
- Hepatic Transaminase Elevations
- Potential for Reduced Efficacy with Estrogen-Containing Contraceptives
Use in Special Populations
- No dose adjustment in women with renal impairment
- No dosage adjustment in women with mild hepatic impairment
- Safety and effectiveness not established in patients less than 18 years of age
Overdose Effects
- Monitoring for signs or symptoms of adverse reactions
- Initiation of appropriate symptomatic treatment
Therapeutic Class
- Gonadotropin-releasing hormone (GnRH) antagonist
Storage Conditions
- Cool and dry place
- Protection from light and moisture
- Keep out of reach of children