Loplate Plus 75 mg+75 mg (Tablet)

Unit Price: ৳ 11.03 (30's pack: ৳ 330.90)

Medicine Details

Category Details
Generic Clopidogrel aspirin
Company Kemiko pharmaceuticals ltd

Title

Loplate Plus

Categories

  • Medicine
  • Health
  • Pharmaceutical

Description

Loplate Plus is indicated for reducing the rate of Myocardial Infarction (MI) and Stroke in patients with non-ST-segment elevation Acute Coronary Syndrome (ACS) and acute ST-segment elevation ACS. It inhibits platelet activation and aggregation through irreversible binding, and is administered orally at a recommended 75 mg once daily dose. It interacts with drugs such as Aspirin and Heparin, and is contraindicated in cases of active pathological bleeding. The therapeutic class is Anti-platelet drugs.

Dimensions

  • Standard tablet size

Color options

  • N/A

Functions

  • Reduces the rate of Myocardial Infarction and Stroke

Materials

  • N/A

Technical specifications

  • Administered orally
  • Recommended 75 mg once daily dose

Design elements

  • N/A

Usability features

  • Well tolerated
  • May prolong bleeding time

Pharmacology

  • Inhibits platelet activation and aggregation
  • Irreversible binding to P2Y12 class of ADP receptors
  • Dose-dependent inhibition of platelet aggregation

Absorption and distribution

  • Rapidly absorbed after oral administration

Metabolism and elimination

  • Extensively metabolized by the liver
  • Approximately 50% excreted in urine and 46% in faeces
  • Elimination half-life of the main circulating metabolite is 8 hours

Dosage and administration

  • Recommended dose of 75 mg once daily with or without food
  • No dosage adjustment for elderly patients or patients with renal impairment
  • Initiated with a single 300 mg loading dose for acute coronary syndrome patients

Interactions

  • Does not modify Clopidogrel-mediated inhibition of ADP-induced platelet aggregation
  • Potentiates the effect of Aspirin on collagen-induced platelet aggregation

Contraindications

  • Hypersensitivity to the drug substance or any component of the product
  • Active pathological bleeding such as peptic ulcer or intracranial hemorrhage

Side effects

  • Generally well tolerated

Pregnancy and lactation

  • Use during first and second trimesters of pregnancy only if clearly needed
  • Contraindicated during the third trimester of pregnancy

Precautions and warnings

  • May prolong bleeding time
  • Rare reports of Thrombotic thrombocytopenic purpura (TTP)
  • Hypersensitivity reactions including rash, angioedema, or hematologic reaction

Pediatric uses

  • Should not be given to children under 12 years, unless benefits outweigh risks

Overdose effects

  • May lead to bleeding complications
  • Moderate intoxication may cause dizziness, headache, and gastrointestinal symptoms
  • Severe intoxication can result in respiratory and metabolic issues

Storage conditions

  • Keep in a cool & dry place (below 30°C)
  • Protected from light & moisture

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