Sinjard-L 25 mg+5 mg (Tablet)

Unit Price: ৳ 40.00 (2 x 7: ৳ 560.00)
Strip Price: ৳ 280.00

Medicine Details

Category Details
Generic Empagliflozin linagliptin
Company Beacon pharmaceuticals plc
Also available as
Sinjard l 10 mg tablet

Indications

  • Adjunct to diet and exercise
  • Improves glycemic control
  • Type 2 diabetes mellitus

Pharmacology

  • Linagliptin inhibits DPP-4 enzyme
  • Increases concentration of active incretin hormones
  • Stimulates insulin release in a glucose-dependent manner
  • Decreases levels of glucagon
  • Empagliflozin is a SGLT2 inhibitor
  • Reduces renal reabsorption of glucose
  • Increases urinary glucose excretion

Dosage & Administration

  • Recommended dose: 10 mg Empagliflozin and 5 mg Linagliptin once daily
  • Increased dose: 25 mg Empagliflozin and 5 mg Linagliptin once daily
  • Assess renal function before initiating
  • Do not initiate if eGFR is below 45 mL/min/1.73 m^2

Interaction

  • Diuretics result in increased urine volume
  • Insulin or Insulin Secretagogues increase risk for hypoglycemia
  • Rifampin decreases Linagliptin exposure
  • SGLT2 inhibitors increase urinary glucose excretion

Contraindications

  • Severe renal impairment
  • Hypersensitivity reaction to Linagliptin or Empagliflozin

Side Effects

  • Pancreatitis
  • Ketoacidosis
  • Volume Depletion
  • Urosepsis and Pyelonephritis
  • Hypoglycemia
  • Genital Mycotic Infections
  • Hypersensitivity Reactions
  • Severe and Disabling Arthralgia
  • Bullous Pemphigoid
  • Heart Failure

Pregnancy & Lactation

  • Not recommended during second and third trimesters
  • Limited data in pregnant women

Precautions & Warnings

  • Pancreatitis risk
  • Ketoacidosis risk
  • Volume Depletion risk
  • Urosepsis and Pyelonephritis risk
  • Hypoglycemia risk
  • Genital Mycotic Infections risk
  • Necrotizing Fasciitis risk
  • Heart Failure risk

Overdose Effects

  • Contact Poison Control Center in case of overdose
  • Employ supportive measures as dictated by clinical status

Therapeutic Class

  • SGLT2 Inhibitors

Storage Conditions

  • Store below 30°C
  • Keep away from light and wet place
  • Keep out of reach of children

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