Genopam 2 mg (Tablet)
Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Clonazepam |
| Company | Veritas pharmaceuticals ltd |
| Also available as |
Indication
- Treatment of panic disorder
- Treatment of panic disorder with or without agoraphobia
- Treatment of Lennox-Gastaut Syndrome
- Treatment of akinetic and myoclonic seizures
- Adjunct in the treatment of absence seizures
- Long-term use effectiveness not systematically studied
Pharmacology
- Exhibits anticonvulsive effects
- Exhibits sedative effects
- Exhibits muscle relaxing effects
- Exhibits anxiolytic effects
- Enhances GABAergic neurotransmission
- Enhances GABA receptor affinity for neurotransmitter
Dosage & Administration
- Initial adult dose not to exceed 1.5 mg/day
- Increased dosage in increments of 0.5 to 1 mg every 3 days
- Maximum recommended daily dose is 20 mg
- Initial adult dose for panic disorder is 0.25 mg
- Initial pediatric dose for infants and children is between 0.01 and 0.03 mg/kg/day
Interaction
- No alteration in pharmacokinetics of phenytoin
- No alteration in pharmacokinetics of carbamazepine
- No alteration in pharmacokinetics of phenobarbital
- Effect on metabolism of other drugs not investigated
Contraindications
- History of hypersensitivity to benzodiazepines
- Clinical or biochemical evidence of significant liver disease
- Contradicted in acute narrow angle glaucoma
Side Effects
- Frequently occurring side effects referable to CNS depression
- Drowsiness in approximately 50% of patients
- Ataxia in approximately 30% of patients
- Behavior problems noted in approximately 25% of patients
Pregnancy & Lactation
- Potential to produce congenital malformations
- Evidence that anticonvulsant drugs act as teratogens
- Compelling indication for administration during pregnancy
Precautions & Warnings
- May increase the incidence of generalized tonic-clonic seizures
- Concomitant use with valproic acid may produce absence status
Use in Special Populations
- Increased production of saliva and bronchial secretion in infants and small children
- Benzodiazepine pharmacologic effects appear to be greater in elderly patients
- Renal impairment does not affect the pharmacokinetics
- Influence of hepatic impairment on pharmacokinetics not fully investigated
Overdose Effects
- Causes drowsiness, ataxia, dysarthria, and nystagmus
- May lead to areflexia, apnoea, hypotension, and coma
- Benzodiazepine respiratory depressant effects more serious in patients with respiratory disease
Therapeutic Class
- Adjunct anti-epileptic drugs
- Benzodiazepine hypnotics
Reconstitution
- Contents of the vial must be diluted with 1 ml of water for injection prior to administration
- Injection solution should be prepared immediately before use
- IV injection should be administered slowly with continuous monitoring
Storage Conditions
- Keep in a dry place away from light and heat
Chemical Structure
- Molecular Formula: C15H10ClN3O3
Common Questions about Genopam 2 mg Tablet
- Not used as a sleeping pill
- Should be taken as long as the doctor has advised
- Withdrawal symptoms include difficulty in sleeping, changes in mood, and increased sweating
- Early symptoms of suicidal thoughts and actions should be monitored
- May cause weight gain and weight loss
- Does not affect memory
- Overdose can cause sleepiness, change in speech, confusion, abnormalities in eye movement