Espazole 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 7.00 (6 x 10: ৳ 420.00)
Strip Price: ৳ 70.00

Medicine Details

Category Details
Generic Esomeprazole
Company Arges life science limited

ProductTitle

Espazole 20 mg Capsule

Categories

  • Medicine
  • Gastric Acid Inhibitor
  • Proton Pump Inhibitor

Description

Esomeprazole is a proton pump inhibitor used to relieve chronic heartburn symptoms, heal erosive esophagitis, eradicate Helicobacter pylori infection, treat Zollinger-Ellison Syndrome, and manage acid-related dyspepsia, duodenal & gastric ulcers.

ColorOptions

  • White

Formulation

Capsule

DosageStrength

20 mg

DosageForm

  • Oral
  • IV Injection
  • IV Infusion

DosageInstructions

  • Take 20 mg or 40 mg Once Daily for 4-8 Weeks for Healing of Erosive Esophagitis
  • Take 20 mg Once Daily for Maintenance of Healing of Erosive Esophagitis
  • Take 20 mg Once Daily for Symptomatic GERD for 4 Weeks
  • Triple Therapy (Esomeprazole 40 mg Once Daily, Amoxicillin 1000 mg Twice Daily, Clarithromycin 500 mg Twice Daily) for Helicobacter Pylori eradication
  • Dose for Zollinger-Ellison Syndrome: 20-80 mg Once Daily
  • Dose for Acid-related Dyspepsia: 20-40 mg Once Daily for 2-4 Weeks
  • Dose for Duodenal Ulcer: 20 mg Once Daily for 2-4 Weeks; Gastric Ulcer: 20-40 mg Once Daily for 4-8 Weeks
  • IV Dosage for Adults: 20 mg or 40 mg once daily, IV Injection: >3 Minutes, IV Infusion: 10-30 minutes
  • IV Dosage for Pediatric Patients: Body weight <55 kg: 10 mg Once daily; Body Weight ≥55 kg: 20 once daily; 1 month to <1 year: 0.5 mg/kg once daily, IV Infusion: 10-30 minutes
  • Dose for Risk reduction of rebleeding of Gastric or Duodenal Ulcers following therapeutic endoscopy in adults: 80 mg, IV Infusion: 30 minutes, followed by a continuous infusion of 8 mg/h for a total treatment duration of 72 hours

AdministrationInstructions

  • TabletOrCapsule: Swallow whole and taken one hour before a meal
  • OralSuspension: Mix with water and drink within 30 minutes; if administered through a tube, follow specific instructions
  • IVInjection: Administered intravenously over a period of at least 3 minutes

Indications

  • Relief from chronic heartburn symptoms
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection
  • Treatment for Zollinger-Ellison Syndrome
  • Management of acid-related dyspepsia
  • Treatment for duodenal & gastric ulcers

Pharmacology

  • MechanismOfAction: Proton pump inhibition, suppression of gastric acid secretion, specific inhibition of the H+/K+-ATPase in the gastric parietal cell
  • Absorption: Peak plasma levels occur at approximately 1.5 hours after oral administration; should be taken at least one hour before meals
  • Distribution: 97% bound to plasma proteins
  • Metabolism: Extensively metabolized in the liver by the CYP enzyme system
  • Excretion: Plasma elimination half-life is approximately 1–1.5 hours; less than 1% of the parent drug is excreted in the urine
  • CombinationTherapy: When used with antimicrobials, there is an increase in AUC and Cmax of Esomeprazole

Interactions

  • Extensively metabolized by CYP2C19 and CYP3A4
  • Not likely to inhibit CYPs 1A2, 2A6, 2C9, 2D6, 2E1, and 3A4
  • Potential interference with the absorption of drugs where gastric pH is crucial
  • Co-administration with certain drugs may impact clearance and plasma levels

Contraindications

Contraindicated in patients with known hypersensitivity to any of the formulation

SideEffects

  • Headache
  • Diarrhea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

PregnancyAndLactation

No adequate and well-controlled studies in pregnant women; excretion in milk not studied; breastfeeding should be discontinued if use is essential

PrecautionsAndWarnings

Symptomatic response does not preclude the presence of gastric malignancy

SpecialPopulationsUse

  • PediatricUse: Safety and effectiveness not established
  • GeriatricUse: No overall differences in safety and efficacy observed
  • HepaticInsufficiency: No dosage adjustment recommended for mild to moderate hepatic insufficiency; caution in severe hepatic insufficiency
  • RenalInsufficiency: Pharmacokinetics not expected to be altered relative to healthy volunteers

OverdoseEffects

  • ToxicEffects: Reduced motor activity, changes in respiratory frequency, tremor, ataxia, intermittent clonic convulsions
  • LethalDose: A single oral dose of Espazole at 510 mg/kg has been lethal to rats
  • Management: Treatment should be symptomatic and supportive

StorageConditions

Store at a temperature not exceeding 30°C in a dry place, protect from light and moisture, keep out of reach of children

ChemicalStructure

  • MolecularFormula: C17H19N3O3S
  • StructureImageURL: https://medex.com.bd/storage/res/g-res-433-esomeprazole-chemical-structure-Tj2Jfp1VmPkRjNXznKqC.svg

CommonQuestions

    • Question: What is Espazole 20 mg Capsule?
    • Answer: PPI used to treat conditions involving excess stomach acid
    • Question: What is Espazole 20 mg Capsule used for?
    • Answer: Relieve heartburn, heal erosive esophagitis, prevent its recurrence
    • Question: What are the side effects of Espazole 20 mg Capsule?
    • Answer: Headache, diarrhea, nausea, flatulence, abdominal pain, constipation, dry mouth
    • Question: Can I take Espazole 20 mg Capsule if I am pregnant or breastfeeding?
    • Answer: Consult your doctor about the risks and benefits
    • Question: How long does it take for Espazole 20 mg Capsule to work?
    • Answer: Usually starts to work within a few hours of taking it
    • Question: Quick Tips
    • Answer:
      • Espazole 20 mg Capsule is well-tolerated and provides long-term relief
      • Avoid eating late at night or before bedtime
      • Inform your doctor if you experience specific symptoms
      • Long-term use can affect bone health and mineral levels

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