Gardi 10 mg (Tablet)
Unit Price: ৳ 3.00 (50's pack: ৳ 150.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Domperidone maleate |
| Company | Arges life science limited |
Brand Name
- Gardi 10 mg Tablet
Category
- Medicine
- Pharmaceutical
Primary Use
- Treat Nausea and Vomiting
- Dyspeptic Symptom Complex
- Delayed Gastric Emptying
- Gastroesophageal Reflux
- Esophagitis
- Parkinson's Disease
- Functional, Organic, Infectious, Dietetic Induced Nausea and Vomiting
- Barium Transit in Radiological Studies
Dosage Form
- Tablet
- Suspension
- Paediatric Drops
- Suppositories
Dosage Instructions
- Take 15-30 minutes before meals
- Maximum Daily Dose for Adults: 80 mg
- Maximum Period of Treatment for Acute Nausea and Vomiting: 12 Weeks
Active Ingredient
- Domperidone
Pharmacological Action
- Dopamine Antagonist
- Gastroprokinetic
- Restores Normal Gastrointestinal Tract Motility and Tone
- Facilitates Gastric Emptying
- Enhances Antral and Duodenal Peristalsis
- Regulates Contraction of the Pylorus
- Increases Esophageal Peristalsis
- Regulates Lower Esophageal Sphincter Pressure
Interaction with Other Drugs
- Anticholinergic Drugs Antagonize Antidyspeptic Effect
- Lower Oral Bioavailability with Simultaneous Antacids and Antisecretory Drugs
- Metabolic Pathway through CYP3A4
- Inhibition by Azole Antifungals, Macrolide Antibiotics, HIV Protease Inhibitors, Nefazodone
- Potential Influence on Absorption of Orally Administered Drugs
Contraindications
- Known Hypersensitivity
- Neonates
- Gastrointestinal Hemorrhage
- Mechanical Obstruction or Perforation
- Prolactin Releasing Pituitary Tumor (Prolactinoma)
Side Effects
- Transient Intestinal Cramps
- Rare Extrapyramidal Phenomena
- Increase in Plasma Prolactin Level
- Galactorrhoea
- Gynaecomastia
- Allergic Reactions like Rash and Urticaria
Pregnancy & Lactation
- Use during First Trimester if Justified by Anticipated Benefit
- Excretion in Breast Milk
- Lower Concentrations in Breast Milk than in Plasma
- Not Recommended for Nursing Mothers Unless Expected Benefits Outweigh Potential Risk
Precautions & Warnings
- Caution in Children due to Increased Risk of Extrapyramidal Reactions
- Use with Caution in Patients with Hepatic Impairment
Special Populations
- Use in Infants with Caution and Close Medical Supervision
- Poor Penetration through Blood-Brain Barrier in Infants
- Caution in Patients with Liver Disorders
- Dosing Frequency Adjustment in Severe Renal Insufficiency
Overdose Effects
- Symptoms: Drowsiness, Disorientation, Extrapyramidal Reactions
- Recommended: Activated Charcoal Administration, Close Observation
- Anticholinergic and Antiparkinson Drugs Helpful in Controlling Reactions
Therapeutic Class
- Motility Stimulants
- Dopamine Antagonist
- Prokinetic Drugs
Storage Conditions
- Store below 30°C
- Protected from Light & Moisture
- Keep out of Children’s Reach
Chemical Structure
C22H24ClN5O2
Molecular Formula
C22H24ClN5O2
Dosage for Adults
- 10-20 mg every 6-8 hours daily
- Maximum Dose: 80 mg daily
Dosage for Children
- 2-4 ml/10 kg body weight every 6-8 hours
- In Dyspeptic Symptom: 0.2-0.4 mg/kg body weight every 6-8 hours
- In Acute and Sub-acute Conditions: 0.2-0.4 mg/kg body weight every 6-8 hours (Maximum treatment period: 12 weeks)
- By Rectum: Maximum daily dose of 30 mg for children weighing 10 to 25 kg
Influence on Ability to Drive and Use Machines
- Does Not Affect Mental Alertness
Common Questions about Gardi 10 mg Tablet
- Used to Treat Nausea and Vomiting
- Relieves Nausea, Vomiting, and Indigestion
- Caution with Alcohol Consumption
- Possible Side Effects: Dizziness, Sleepiness, Dry Mouth
- Not Recommended for Long-term Use without Consulting Doctor