Nouranz 10 mg (Tablet)
Unit Price: ৳ 10.00 (20's pack: ৳ 200.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ketorolac tromethamine |
| Company | Arges life science limited |
Indications
- Short-term management of post-operative pain
- Relief of ocular surgery-related pain and inflammation
- Treatment for eye inflammation and redness caused by allergies
Description
- Pyrrolo-pyrrole group nonsteroidal anti-inflammatory drug (NSAID)
- Chemical compound structure: 5 benzoyle-2,3-dihydro-1H-pyrroligine-1-carboxylic acid, compound with 2-amino-2-(hydroxymethyl)-1,3-propanediol
- Inhibits prostaglandin synthesis
- Peripherally acting analgesic
- Biological activity associated with S-form
- Linear pharmacokinetic property
- Highly protein bound
- Largely metabolized in the liver
- Metabolites and unchanged drugs excreted in urine
Pharmacology
- Potent analgesic
- Non-steroidal anti-inflammatory drug (NSAID)
- Inhibits cyclooxygenase enzyme system
- Minimal anti-inflammatory effect at analgesic dose
Dosage & Administration
- Recommended tablet dose: 10 mg every 4-6 hours for short-term use (up to 7 days)
- Injection: Single or multiple doses for moderately severe acute pain management, with specific dosing guidelines based on age, weight, and condition
- Eye drops: Recommended use of 1 drop in each eye 4 times daily
Interaction
- Increased side effects with other NSAIDs or aspirin
- Enhanced anti-coagulant effect with anti-coagulants
- Reduced anti-hypertensive effect with beta blockers
- Increased risk of renal impairment with ACE inhibitors
- Enhanced toxicity of methotrexate
Contraindications
- Hypersensitivity to Ketorolac or other NSAIDs
- Not for use in children under 16 years old
- Contraindicated as prophylactic analgesic before surgery
Side Effects
- Nausea
- Vomiting
- Gastro-intestinal bleeding
- Melena
- Peptic ulcer
- Pancreatitis
- Anxiety
- Drowsiness
- Headache
- Excessive thirst
- Fatigue
- Bradycardia
- Hypertension
- Palpitation
- Chest pain
- Infertility in females
- Pulmonary edema
Pregnancy & Lactation
- US FDA Pregnancy category: C
- Avoid use in pregnancy and lactation unless benefits outweigh risks
Precautions & Warnings
- Exercise caution in patients over 65 years old
- Monitor patients with active or suspected peptic ulcer, gastrointestinal bleeding, asthma, or liver dysfunction
- Immediate discontinuation and close monitoring for corneal health in patients with corneal epithelial breakdown using topical NSAIDs
- Avoid administering while wearing contact lenses
Therapeutic Class
- Drugs used for Rheumatoid Arthritis
- Non-Opioid Analgesics
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children