Olzep 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 5.00 (60's pack: ৳ 300.00)

Medicine Details

Category	Details
Generic	Omeprazole
Company	Arges life science limited

Gastric and duodenal ulcer
NSAID-associated duodenal and gastric ulcer
As prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
Gastro-esophageal reflux disease
Long-term management of acid reflux disease
Acid-related dyspepsia
Severe ulcerating reflux esophagitis
Prophylaxis of acid aspiration during general anesthesia
Zollinger-Ellison syndrome
Helicobacter pylori-induced peptic ulcer

20 mg once daily for benign gastric and duodenal ulcer
40 mg daily for severe or recurrent cases
10-20 mg daily for prevention of relapse in duodenal ulcer
20 mg once daily for NSAID-associated duodenal or gastric ulcer
20 mg once daily for gastro-esophageal reflux disease
40 mg once daily for refractory gastro-esophageal reflux disease
10-20 mg daily for long-term management of acid reflux disease
10-20 mg once daily for acid-related dyspepsia
40 mg on the preceding evening, then 40 mg 2-6 hours before surgery for prophylaxis of acid aspiration
60 mg once daily for Zollinger-Ellison syndrome
20 mg twice daily for Helicobacter pylori eradication regimen in peptic ulcer disease
10-20 mg once daily for 4-12 weeks in severe ulcerating reflux esophagitis (Child > 1 year)
40 mg for intravenous prophylaxis of acid aspiration
40 mg once daily for intravenous treatment of duodenal ulcer, gastric ulcer or reflux esophagitis
60 mg daily for Zollinger-Ellison syndrome intravenous treatment

Omeprazole is for intravenous administration only
IV injection should be given slowly over a period of at least 2 to 5 minutes at a maximum rate of 4 ml/minute
Use only freshly prepared solution for IV injection
IV infusion should be given over a period of 20-30 minutes or more
Reconstituted solution should not be mixed or co-administered with any other drug

Decreased intragastric acidity may reduce absorption of ketoconazole
Metabolised in the liver through cytochrome P450
Can delay the elimination of diazepam, phenytoin and warfarin
Plasma concentrations of Olzep and clarithromycin are increased during concomitant administration
No evidence of interaction with phenacetin, theophylline, caffeine, propranolol, metoprolol, cyclosporin, lidocaine, quinidine, estradiol, amoxycillin, or antacids
No evidence of interaction with piroxicam, diclofenac or naproxen
Simultaneous treatment with Olzep and digoxin leads to a 10% increase in the bioavailability of digoxin due to increased intragastric pH

Skin rash, urticaria and pruritus
Photosensitivity, bullous eruption, erythema multiforme, angioedema and alopecia
Diarrhoea and headache
Constipation, nausea/vomiting, flatulence and abdominal pain
Dry mouth, stomatitis and candidiasis
Paraesthesia, dizziness, light headedness and feeling faint
Somnolence, insomnia and vertigo
Reversible mental confusion, agitation, depression and hallucinations
Arthritic and myalgic symptoms
Blurred vision, taste disturbance, peripheral oedema, increased sweating, gynaecomastia, leucopenia, thrombocytopenia, agranulocytosis, pancytopenia, anaphylactic shock, malaise, fever, bronchospasm, encephalopathy, hepatitis with or without jaundice, interstitial nephritis, hepatic failure, increases in liver enzymes

No adverse effects on pregnancy or on the health of the fetus/newborn child based on epidemiological studies
Omeprazole can be used during pregnancy
No information available on the passage of Omeprazole into breast milk or its effects on the neonate
Breastfeeding should be discontinued if the use of Omeprazole is considered essential
Safety and effectiveness not established in pediatric patients less than 18 years of age

Avoid concomitant use of clopidogrel and Omeprazole
Increased risk for osteoporosis-related fractures with PPI therapy
Atrophic gastritis noted occasionally in gastric corpus biopsies from long-term treated patients
Concomitant use of PPIs with methotrexate may lead to methotrexate toxicities