Pulbo 801 mg (Tablet)

Unit Price: ৳ 125.00 (1 x 10: ৳ 1,250.00)
Strip Price: ৳ 1,250.00

Medicine Details

Category Details
Generic Pirfenidone
Company Opsonin pharma ltd
Also available as
Pulbo 534 mg tablet Pulbo 267 mg capsule

Indications

  • Treatment of mild to moderate Idiopathic Pulmonary Fibrosis (IPF)

Pharmacology

  • Anti-inflammatory properties
  • Antioxidant properties
  • Anti-fibrotic properties
  • Improvement of lung function
  • Reduction of acute exacerbations in patients with IPF
  • Suppression of TGF-β1
  • Downregulation of pro-inflammatory cytokines
  • Inhibition of inflammatory cell influx
  • Inhibition of increased pulmonary vascular permeability

Dosage & Administration

  • Oral route of administration
  • Titration of dose over a 14-day period
  • Recommended daily dose of three 267 mg tablets or one 801 mg tablet three times a day with food
  • Dose adjustments for gastrointestinal events
  • Dose adjustments for photosensitivity reaction or rash
  • Dose adjustments for hepatic function
  • Resumption of dose after treatment interruption
  • Recommendation for missed doses

Interaction

  • Moderate and strong CYP1A2 inhibitors interaction
  • Effect of food on reducing adverse reactions

Contraindications

  • Hypersensitivity to the active substance or excipients
  • Concomitant use of fluvoxamine
  • Severe hepatic impairment
  • End-stage liver disease
  • Severe renal impairment or end-stage renal disease requiring dialysis

Side Effects

  • Common side effects: nausea, rash, abdominal pain, upper respiratory tract infection, diarrhea, fatigue, headache, dyspepsia, dizziness, vomiting, anorexia, gastroesophageal reflux disease, sinusitis, insomnia, weight decrease, arthralgia
  • Rare side effects: photosensitivity reaction, decreased appetite, pruritus, asthenia, dysgeusia, non-cardiac chest pain

Pregnancy & Lactation

  • Precaution to avoid use during pregnancy
  • Unknown excretion in human milk
  • Risk to the suckling child
  • Effect on fertility

Precautions & Warnings

  • Elevated liver enzymes monitoring
  • Photosensitivity and rash precautions
  • Gastrointestinal disorders precautions

Use in Special Populations

  • Safety and efficacy in children & adolescents unknown
  • Monitoring and dosage modification for hepatic impairment
  • Monitoring and dosage modification for renal impairment
  • Altered exposure in smokers

Overdose Effects

  • Limited clinical experience with overdose
  • Mild, transient adverse reactions

Therapeutic Class

  • Immunosuppressant

Storage Conditions

  • Cool and dry storage
  • Protection from light and moisture
  • Keep out of reach of children

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