Pulbo 267 mg (Capsule)
Unit Price: ৳ 45.00 (3 x 10: ৳ 1,350.00)
Strip Price: ৳ 450.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Pirfenidone |
| Company | Opsonin pharma ltd |
| Also available as |
Indications
- Treatment of mild to moderate Idiopathic Pulmonary Fibrosis (IPF) in adults
Pharmacology
- Anti-inflammatory properties
- Antioxidant properties
- Anti-fibrotic properties
- Improvement of lung function
- Reduction of acute exacerbations in IPF patients
- Suppression of TGF-β1
- Downregulation of pro-inflammatory cytokines
- Inhibition of inflammatory cells and pulmonary vascular permeability in animal models
Dosage & Administration
- Route of administration: Orally with food
- Titration for initiating treatment in adults
- Dose adjustments for gastrointestinal events
- Dose adjustments for photosensitivity reaction or rash
- Dose adjustments for hepatic function
- Re-initiation of therapy after missing treatment
- Resumption of dose after treatment interruption
Interaction
- Moderate and strong CYP1A2 inhibitors increase systemic exposure
- Dosage reduction with use of CYP1A2 inhibitors
- Reduced incidence of adverse reactions in fed group
Contraindications
- Hypersensitivity to active substance or excipients
- Concomitant use of fluvoxamine
- Severe hepatic impairment
- Severe renal impairment or end stage renal disease requiring dialysis
Side Effects
- Common: Nausea, rash, abdominal pain, upper respiratory tract infection, diarrhea, fatigue, headache, dyspepsia, dizziness, vomiting, anorexia, gastroesophageal reflux disease, sinusitis, insomnia, weight decrease, arthralgia
- Rare: Photosensitivity reaction, decreased appetite, pruritus, asthenia, dysgeusia, non-cardiac chest pain
Pregnancy & Lactation
- Precaution to avoid use during pregnancy
- Unknown excretion in human milk
- Potential effects on fetal viability
- Precaution to discontinue breast-feeding or Pirfenidone therapy if necessary
- No effects on fertility observed in rats
Precautions & Warnings
- Monitoring of elevated liver enzymes
- Monitoring for photosensitivity and rash
- Monitoring for gastrointestinal disorders
Use in Special Populations
- Safety and efficacy in children & adolescents not known
- Monitoring and dosage modification for hepatic impairment
- Monitoring and dosage modification for renal impairment
- Decreased exposure noted in smokers
Overdose Effects
- Limited clinical experience with overdose
- Mild, transient adverse reactions observed in healthy volunteers
Therapeutic Class
- Immunosuppressant
Storage Conditions
- Cool & dry place
- Protection from light & moisture
- Keep out of reach of children