Pulmidone 267 mg (Tablet)

Unit Price: ৳ 45.00 (2 x 10: ৳ 900.00)
Strip Price: ৳ 450.00

Medicine Details

Category Details
Generic Pirfenidone
Company Beximco pharmaceuticals ltd
Also available as
Pulmidone 801 mg tablet

Indications

  • Treatment of mild to moderate Idiopathic Pulmonary Fibrosis (IPF) in adults

Pharmacology

  • Anti-inflammatory
  • Antioxidant
  • Anti-fibrotic properties
  • Improves lung function
  • Reduces acute exacerbations in IPF patients
  • Suppresses TGF-β1
  • Downregulates pro-inflammatory cytokines
  • Inhibits inflammatory cell influx
  • Reduces pulmonary vascular permeability induced by bleomycin

Dosage & Administration

  • Oral route of administration
  • Recommended daily dose titration
  • Dose adjustment for gastrointestinal events
  • Dose adjustment for photosensitivity reactions or rash
  • Dose adjustment for hepatic function
  • Re-initiation of therapy after treatment interruption
  • Resumption of dose after interruption of less than 14 days
  • Instructions for use with food

Interactions

  • Interactions with moderate and strong CYP1A2 inhibitors
  • Dosage adjustments with ciprofloxacin use
  • Different adverse reaction incidence observed in fed vs. fasted state

Contraindications

  • Hypersensitivity to active substance or excipients
  • Concomitant use of fluvoxamine
  • Severe hepatic impairment or end-stage liver disease
  • Severe renal impairment (CrCl <30 ml/min) or end-stage renal disease requiring dialysis

Side Effects

  • Common: nausea, rash, abdominal pain, upper respiratory tract infection, diarrhea, fatigue, headache, dyspepsia, dizziness, vomiting, anorexia, gastroesophageal reflux disease, sinusitis, insomnia, weight decrease, arthralgia
  • Rare: photosensitivity reaction, decreased appetite, pruritus, asthenia, dysgeusia, non-cardiac chest pain

Pregnancy & Lactation

  • Precautionary avoidance during pregnancy
  • Unknown excretion in human milk
  • Effects on fertility and reproductive performance in rats

Precautions & Warnings

  • Monitoring and dosage modifications for elevated liver enzymes
  • Monitoring and dosage modifications for photosensitivity and rash
  • Monitoring and dosage modifications for gastrointestinal disorders
  • Use in special populations: children & adolescents, hepatic impairment, renal impairment, smokers

Use in Special Populations

  • Safety and efficacy in children & adolescents not established
  • Monitoring and dosage modifications for hepatic impairment
  • Monitoring and dosage modifications for renal impairment
  • Altered exposure in smokers

Overdose Effects

  • Limited clinical experience with overdose
  • Mild, transient adverse reactions

Therapeutic Class

  • Immunosuppressant

Storage Conditions

  • Cool and dry storage
  • Protection from light and moisture
  • Keep out of reach of children

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