Tolema 200 mg (Tablet)
Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Tolfenamic acid |
| Company | Biopharma limited |
Title
- Tolema 200 mg Tablet
Categories
- Pain Relief
- Analgesic
- NSAID
Description
- Potent inhibitor of cyclooxygenase enzyme
- Relieves pain of migraine headache
- Used as an analgesic in post-operative pain and fever
Indications
- Relieving the pain of migraine headache
- Recommended for use as an analgesic in post-operative pain and fever
Mode of Action
- Inhibits the synthesis of inflammatory mediators
- Direct antagonistic action on prostaglandin receptors
Pharmacology
- Potent inhibitor of cyclooxygenase enzyme
- Inhibits the synthesis of inflammatory mediators
- Direct antagonistic action on prostaglandin receptors
- Absorbed from GI tract
- Peak plasma concentration after 60-90 min
- Bioavailability of 85%
- Protein-binding: 99%
- Plasma half-life of 2 hours
- Metabolized in the liver
- Excreted in urine and feces
Dosage & Administration
- 200 mg for acute migraine attacks
- 100-200 mg tid for mild to moderate pain
- Dose adjustments for renal impairment
- Avoid in severe renal impairment
Interactions
- Increased absorption with Metoclopramide and Magnesium hydroxide
- Decreased absorption with Aluminium hydroxide
- Risk of bleeding with anticoagulants and other NSAIDs
- Decreased antihypertensive response to loop diuretics, B-blockers, and ACE Inhibitors
- Increased plasma concentration of Lithium, Methotrexate, and cardiac glycosides
- Increased risk of nephrotoxicity with ACE inhibitors, Ciclosporin, Tacrolimus, or diuretics
Contraindications
- Active gastro-intestinal bleeding
- Active gastro-intestinal ulceration
- Severe heart failure
- History of gastro-intestinal bleeding related to previous NSAID therapy
- History of recurrent gastro-intestinal ulceration
Side Effects
- Alveolitis
- Hepatic damage
- Pancreatitis
- Pulmonary eosinophilia
- Stevens-johnson syndrome
- Angioedema
- Blood disorder
- Depression
- Diarrhea
- Dizziness
- Drowsiness
- Dysuria
- Euphoria
- Gastro-intestinal bleeding
- Hallucination
- Insomnia
- Malaise
- Nausea
- Hearing disturbances
- Rash
- Visual disturbances
- Vertigo
- Raised blood pressure
Pregnancy & Lactation
- Not recommended during pregnancy unless essential
- Avoid in the third trimester of pregnancy
- NSAIDs can appear in breast milk in very low concentrations
Precautions & Warnings
- Patients with asthma bronchospasm
- Patients with bleeding disorders
- Patients with cardiovascular diseases
- Patients with peptic ulceration
- Patients with hypertension
- Patients with liver infection
- Patients with cardiac or renal function impairment
- Elderly patients
Overdose Effects
- Headache
- Nausea
- Vomiting
- Gastro-intestinal bleeding
- Diarrhea
- Coma
- Drowsiness
- Dizziness
- Tinnitus
- Fainting
- Convulsions
- Acute renal failure
- Liver damage
- Symptomatic treatment required
Therapeutic Class
- Drugs used for Rheumatoid Arthritis
- Non-steroidal Anti-inflammatory Drugs (NSAIDs)
- Other drugs for migraine
Storage Conditions
- Store in a cool and dry place
- Keep away from light
- Keep out of the reach of children
Chemical Structure
- Molecular Formula: C14H12ClNO2
- Chemical Structure Image URL: https://medex.com.bd/storage/res/g-res-1092-tolfenamic-acid-chemical-structure-dzPweN5r9IE4mD1xFrIL.svg
Common Questions
- What is Tolema 200 mg Tablet?
- What are the uses of Tolema 200 mg Tablet?
- Quick Tips: taken with food or milk to avoid upset stomach, can cause serious complications like stomach bleeding and kidney problems if taken for a long time, can raise the risk of blood clots, heart attack, or stroke, inform doctor if pregnant or planning to conceive or breastfeeding, inform doctor if ever diagnosed with kidney or liver problems