Lamitrin ER 100 mg (Tablet (Extended Release))

Unit Price: ৳ 30.00 (3 x 10: ৳ 900.00)
Strip Price: ৳ 300.00

Medicine Details

Category Details
Generic Lamotrigine
Company Aci limited
Also available as
Lamitrin 25 mg tablet Lamitrin 50 mg tablet Lamitrin 2 mg tablet Lamitrin 5 mg tablet Lamitrin er 50 mg tablet

Indications

  • Adjunctive therapy for partial-onset seizures
  • Adjunctive therapy for primary generalized tonic-clonic seizures
  • Adjunctive therapy for generalized seizures of Lennox-Gastaut syndrome
  • Monotherapy for epilepsy in patients aged 16 years and older
  • Treatment for bipolar disorder in patients aged 18 years and older

Drug Category

Antiepileptic drug (AED)

Pharmacology

  • Inhibition of voltage-sensitive sodium channels
  • Stabilization of neuronal membranes
  • Inhibition of presynaptic excitatory neurotransmitter release
  • Binding properties to several different receptors

Dosage & Administration

  • Escalation regimen for patients with epilepsy aged over 12 years
  • Escalation regimen for patients with epilepsy aged 2 to 12 years
  • Escalation regimen for adults with bipolar disorder
  • Initial weight-based dosing guide for patients aged 2 to 12 years taking Valproate with epilepsy

Drug Interactions

  • Valproate increases concentrations by more than 2-fold
  • Carbamazepine, phenytoin, phenobarbital, primidone, and rifampin decrease concentrations by approximately 40%
  • Estrogen-containing oral contraceptives decrease concentrations by approximately 50%
  • Protease inhibitors lopinavir/ritonavir and atazanavir/ritonavir decrease exposure by approximately 32-50%

Side Effects

  • Dizziness
  • Headache
  • Diplopia
  • Nausea
  • Blurred vision
  • Somnolence
  • Pharyngitis
  • Rash
  • Vomiting
  • Diarrhea
  • Infection
  • Fever
  • Abdominal pain
  • Tremor

Pregnancy & Lactation

Pregnancy Category C. Excreted in human milk. A decision should be made whether to discontinue nursing or discontinue the drug.

Precautions & Warnings

  • Discontinue at the first sign of rash
  • Monitor for blood dyscrasias
  • Monitor for suicidal behavior and ideation
  • Monitor for signs of aseptic meningitis

Use in Special Populations

  • Safety and effectiveness in very young pediatric patients aged 1 to 24 months not demonstrated
  • Safety and effectiveness for the maintenance treatment of bipolar disorder not established in pediatric patients aged 10 to 17 years

Overdose Effects

  • Ataxia
  • Nystagmus
  • Seizures
  • Decreased level of consciousness
  • Coma
  • Intraventricular conduction delay

Therapeutic Class

Primary anti-epileptic drugs

Storage Conditions

Keep out of reach of children. Store in a dry place, below 25°C temperature, and protected from light

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