Othera 40 mg/vial (IV Injection)
40 mg vial: ৳ 120.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Esomeprazole mups preparation |
| Company | Aci limited |
| Also available as |
Title
Othera MUPS Tablet 20/40 mg
Categories
- Medicine
- Healthcare
- Digestive Health
Indications
- Gastro-esophageal Reflux Disease (GERD)
- Risk reduction in NSAID associated gastric ulcer
- H. pylori eradication (Triple therapy)
- Zollinger-Ellison syndrome and idiopathic hypersecretion
Composition
- Esomeprazole MUPS 20 Tablet - 20 mg Esomeprazole (as Esomeprazole Magnesium Trihydrate USP)
- Esomeprazole MUPS 40 Tablet - 40 mg Esomeprazole (as Esomeprazole Magnesium Trihydrate USP)
Description
- MUPS is abbreviation for Multiple-Unit Pellet System
- Ensures greater bioavailability
- Uniform emptying of micro pellets from stomach into small intestine
- Combines advantages of tablets and pellet-filled capsules
- Rapid and uniform gastric emptying
- Uniform drug release
- Once daily dosing
- Better drug absorption
- Reduces esophageal residence time
- Minimizes fluctuation in plasma concentration of drug
- Facilitates consistent and controlled pharmacological action
Mode of Action
- Inhibits gastric acid by blocking the proton pump of the gastric parietal cell
- Effective for short-term treatment of gastric and duodenal ulcers
- Prevention and treatment of NSAID associated gastric ulcers
Dosage
- Erosive esophagitis - Adult: 40 mg once daily for 4 weeks, Children & adolescents: 40 mg once daily for 4 weeks
- Maintenance of healing of erosive esophagitis - Adult: 20 mg once daily, Children & adolescents: 20 mg once daily
- Risk reduction in NSAID associated gastric ulcer - Adult: 20 mg once daily for 4-8 weeks
- H. pylori eradication - Adult: 20 mg twice daily for 7 days, Children & adolescents: 20 mg twice daily for 7 days
- Zollinger-Ellison syndrome and idiopathic hypersecretion - Adult: 40-80 mg twice daily, Children 1-11 years: 10 mg or 20 mg once daily (weight dependent)
Administration
- Tablets should be swallowed whole with liquid
- Can be dispersed in half a glass of non-carbonated water if needed
- Pellets must not be chewed or crushed
Interaction
- Metabolized in the liver by CYP2C19 and CYP3A4
- No clinically relevant interactions with certain CYP enzymes expected
- May interfere with the absorption of drugs where gastric pH is important
- Potential for interfering with CYP2C19, the major metabolizing enzyme
- Combination Therapy with Clarithromycin increases plasma levels
Contraindications
- Contraindicated in patients with known hypersensitivity
Side Effects
- Headache
- Diarrhoea
- Nausea
- Flatulence
- Abdominal pain
- Constipation
- Dry mouth
Pregnancy & Lactation
- Caution advised
- Unknown if Esomeprazole or its metabolites appear in human breast milk
Precautions & Warnings
- Use with caution in severe liver dysfunction and severe renal impairment
- May slightly increase the risk of hip, wrist and spine fractures
Storage Conditions
- Store below 25°C
- Protect from light
- Keep out of reach of children
Chemical Structure
- Molecular Formula: C17H19N3O3S
- Chemical Structure Image: https://medex.com.bd/storage/res/g-res-433-esomeprazole-chemical-structure-Tj2Jfp1VmPkRjNXznKqC.svg