Unicus 40 mg (MUPS Tablet)

Unit Price: ৳ 14.00 (3 x 10: ৳ 420.00)
Strip Price: ৳ 140.00

Medicine Details

Category Details
Generic Esomeprazole mups preparation
Company General pharmaceuticals ltd
Also available as
Unicus 20 mg tablet

Title

Unicus MUPS Tablet

Categories

  • Medicine
  • Gastroenterology
  • Pharmaceuticals

Description

Proton pump inhibitor used for treating gastro-esophageal reflux disease (GERD), risk reduction in NSAID associated gastric ulcer, H. pylori eradication, Zollinger-Ellison syndrome, and idiopathic hypersecretion.

Dimensions

Various tablet sizes available, such as 20mg and 40mg

Color options

    Functions

    • Reduces gastric acid production
    • Prevents and treats gastric and duodenal ulcers
    • Aids in H. pylori eradication
    • Relieves heartburn and GERD symptoms
    • Helps in healing erosive esophagitis
    • Prevents erosive esophagitis recurrence

    Materials

      Technical specifications

      • Molecular Formula: C17H19N3O3S

      Design elements

      • MUPS (Multiple-Unit Pellet System): Compaction of modified release coated multiparticulates or pellets
      • Enteric coated pellets: Ensures greater bioavailability and uniform drug release

      Usability features

      • Dosage Form: Tablet
      • Administration: Swallow whole with liquid, can be dispersed in water if needed
      • Storage Conditions: Cool & dry place below 25°C, protect from light

      Pharmacology

      • Mode of Action: Inhibits gastric acid by blocking the proton pump of the gastric parietal cell

      Indications

      • Gastro-esophageal Reflux Disease (GERD)
      • Risk reduction in NSAID associated gastric ulcer
      • H. pylori eradication (Triple therapy)
      • Zollinger-Ellison syndrome and idiopathic hypersecretion

      Dosage

      • Erosive esophagitis:
        • Adult (≥18 years): 40 mg once daily for 4 weeks
        • Children & adolescents (12-18 years): 40 mg once daily for 4 weeks
      • Maintenance of healing of erosive esophagitis:
        • Adult (≥18 years): 20 mg once daily
        • Children & adolescents (12-18 years): 20 mg once daily

      Interaction

      • Metabolism: Extensively metabolized in the liver by CYP2C19 and CYP3A4
      • Inhibitory Effects:
        • Not likely to inhibit CYPs 1A2, 2A6, 2C9, 2D6, 2E1, and 3A4
        • May interfere with the absorption of drugs affected by gastric pH
      • Combination Therapy with Clarithromycin: Results in increases in the plasma levels of Unicus and 14-hydroxyclarithromycin

      Contraindications

      Known hypersensitivity to any of the formulation

      Side effects

      • Headache
      • Diarrhoea
      • Nausea
      • Flatulence
      • Abdominal pain
      • Constipation
      • Dry mouth

      Pregnancy lactation

      Caution advised, not known if Esomeprazole or its metabolites appear in human breast milk

      Precautions warnings

      • Severe Conditions: Careful usage in severe liver dysfunction and severe renal impairment
      • Long-term Use: May slightly increase the risk of hip, wrist, and spine fracture

      Compound summary

      • Chemical Structure: C17H19N3O3S

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