Esmosec 40 mg/vial (IV Injection)

40 mg vial: ৳ 95.00

Medicine Details

Category	Details
Generic	Esomeprazole
Company	Techno drugs ltd
Also available as	Esmosec 20 mg tablet Esmosec 40 mg tablet

Title

Esmosec 40 mg/vial Injection

Categories

Medicine
Pharmaceuticals
Gastroenterology

Description

Proton pump inhibitor indicated for various gastrointestinal conditions

Indications

Relief from chronic heartburn symptoms
Healing of erosive esophagitis
Maintenance of healing of erosive esophagitis
Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
Zollinger-Ellison Syndrome
Acid-related Dyspepsia
Duodenal & Gastric ulcer

Mode of Action

Suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase in the gastric parietal cell
First single optical isomer of proton pump inhibitor

Absorption

Enteric-coated pellet formulation of esomeprazole magnesium
Peak plasma levels occur at approximately 1.5 hours

Distribution

97% bound to plasma proteins
Apparent volume of distribution at steady state in healthy volunteers is approximately 16 L

Metabolism

Extensively metabolized in the liver by the cytochrome P450 (CYP) enzyme system
Metabolites lack anti-secretory activity

Excretion

Plasma elimination half-life is approximately 1–1.5 hours
80% of an oral dose is excreted as inactive metabolites in the urine

Dosage (Oral)

20 mg or 40 mg Once Daily for 4-8 Weeks for healing of erosive esophagitis
20 mg Once Daily for maintenance of healing of erosive esophagitis
20 mg Once Daily for symptomatic GERD

Dosage (IV Injection or Infusion)

20 mg or 40 mg once daily for Adult Patients
Different dosages for Pediatric Patients based on body weight
80 mg for adult patients for risk reduction of rebleeding of gastric or duodenal ulcers following therapeutic endoscopy

Administration

Tablet or capsule should be swallowed whole and taken one hour before a meal
Oral Suspension should be taken with water and administered through a nasogastric or gastric tube if necessary
IV Injection administered over a period of at least 3 minutes

Interactions

Extensively metabolized in the liver by CYP2C19 and CYP3A4
No clinically relevant interactions with drugs metabolized by certain CYP enzymes expected
May interfere with the absorption of drugs where gastric pH is important for bioavailability

Contraindications

Known hypersensitivity to any of the formulation

Side Effects

Headache
Diarrhoea
Nausea
Flatulence
Abdominal pain
Constipation
Dry mouth

Pregnancy & Lactation

No adequate and well-controlled studies in pregnant women
Breastfeeding should be discontinued if the use of esomeprazole is considered essential

Precautions & Warnings

Symptomatic response to therapy does not preclude the presence of gastric malignancy
Instructions for patients who have difficulty swallowing capsules
Antacids may be used while taking esomeprazole

Use in Special Populations

Safety and effectiveness in paediatric patients have not been established
No overall differences in safety and efficacy observed between the elderly and younger individuals
No dosage adjustment recommended for patients with mild to moderate hepatic insufficiency
Pharmacokinetics not expected to be altered in patients with renal impairment

Overdose Effects

Acute toxicity observed in rats with high doses
No reports of overdose with esomeprazole
No specific antidote known
Treatment should be symptomatic and supportive

Storage Conditions

Store at a temperature not exceeding 30°C in a dry place
Protect from light and moisture
Keep out of reach of children

Chemical Structure

Molecular Formula: C17H19N3O3S
Chemical Structure Image

Commonly Asked Questions

Esmosec 40 mg/vial Injection is used to treat gastroesophageal reflux disease (GERD), ulcers, and other conditions that involve too much stomach acid
Eases heartburn and relieves GERD symptoms
May cause common side effects like headaches, diarrhea, nausea, gas, stomach pain, constipation, and dry mouth

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