Parnil DS 400 mg (Chewable Tablet)

Unit Price: ৳ 5.00 (25 x 2: ৳ 250.00)
Strip Price: ৳ 10.00

Medicine Details

Category Details
Generic Albendazole
Company Euro pharma ltd

Indications

  • Single infestation of hookworm (Ancylostoma)
  • Mixed infestation of roundworm (Ascaris) and threadworm (Enterobius)
  • Infestation of whipworm (Trichuris)
  • Infestation of strongyloides
  • Infestation of tapeworm
  • Infestation of opisthorchi
  • Indicated in hydatid disease

Description

  • Benzimidazole anthelmintic
  • Active against most nematodes and some cestodes
  • Treatment of intestinal nematode infections
  • Treatment of hydatid disease
  • Vermicidal, ovicidal, and larvicidal activity
  • Inhibitory effect on tubulin polymerization

Pharmacology

  • Broad spectrum anthelmintic
  • Blocks glucose uptake in susceptible helminths
  • Depletes energy level of helminths
  • Leads to immobilization of parasite
  • Inhibition of parasite tubulin polymerization
  • Extensively metabolized, probably in the liver
  • Poorly absorbed from the gastrointestinal tract

Dosage & Administration

  • Recommended dose for adults and children over 2 years: 400 mg as a single dose for various infections
  • Specific dosages for different types of infestations
  • Not recommended for children under 1 year
  • Different treatment duration and dosage for hydatid disease
  • Treatment duration and dosage for giardiasis

Interaction

  • No reported pharmacodynamic or pharmacokinetic interaction

Contraindications

  • Not normally used in neonates
  • Potential dose reduction for children weighing less than 10 kg
  • Avoid in pregnant women
  • No evidence to alter dose in renal, hepatic, or cardiac failure

Side Effects

  • Gastrointestinal disturbances
  • Headache
  • Dizziness
  • Changes in liver enzymes
  • Reversible alopecia (rare)
  • Rash and fever
  • Blood disorders including leucopenia and pancytopenia
  • Allergic shock if cyst leakage
  • Convulsion and meningism in cerebral disease

Pregnancy & Lactation

  • US FDA Pregnancy category of Albendazole is C
  • Avoid in pregnancy and lactation unless benefits outweigh risks

Precautions & Warnings

  • Blood counts and liver function tests before treatment and during each cycle
  • Exclusion of pregnancy before starting treatment
  • Constant medical supervision and monitoring for Echinococcosis treatment

Therapeutic Class

  • Anthelmintic

Storage Conditions

  • Keep in a dry place
  • Away from light and heat
  • Keep out of the reach of children

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