Parnil DS 400 mg (Chewable Tablet)
Unit Price: ৳ 5.00 (25 x 2: ৳ 250.00)
Strip Price: ৳ 10.00
Medicine Details
Category | Details |
---|---|
Generic | Albendazole |
Company | Euro pharma ltd |
Indications
- Single infestation of hookworm (Ancylostoma)
- Mixed infestation of roundworm (Ascaris) and threadworm (Enterobius)
- Infestation of whipworm (Trichuris)
- Infestation of strongyloides
- Infestation of tapeworm
- Infestation of opisthorchi
- Indicated in hydatid disease
Description
- Benzimidazole anthelmintic
- Active against most nematodes and some cestodes
- Treatment of intestinal nematode infections
- Treatment of hydatid disease
- Vermicidal, ovicidal, and larvicidal activity
- Inhibitory effect on tubulin polymerization
Pharmacology
- Broad spectrum anthelmintic
- Blocks glucose uptake in susceptible helminths
- Depletes energy level of helminths
- Leads to immobilization of parasite
- Inhibition of parasite tubulin polymerization
- Extensively metabolized, probably in the liver
- Poorly absorbed from the gastrointestinal tract
Dosage & Administration
- Recommended dose for adults and children over 2 years: 400 mg as a single dose for various infections
- Specific dosages for different types of infestations
- Not recommended for children under 1 year
- Different treatment duration and dosage for hydatid disease
- Treatment duration and dosage for giardiasis
Interaction
- No reported pharmacodynamic or pharmacokinetic interaction
Contraindications
- Not normally used in neonates
- Potential dose reduction for children weighing less than 10 kg
- Avoid in pregnant women
- No evidence to alter dose in renal, hepatic, or cardiac failure
Side Effects
- Gastrointestinal disturbances
- Headache
- Dizziness
- Changes in liver enzymes
- Reversible alopecia (rare)
- Rash and fever
- Blood disorders including leucopenia and pancytopenia
- Allergic shock if cyst leakage
- Convulsion and meningism in cerebral disease
Pregnancy & Lactation
- US FDA Pregnancy category of Albendazole is C
- Avoid in pregnancy and lactation unless benefits outweigh risks
Precautions & Warnings
- Blood counts and liver function tests before treatment and during each cycle
- Exclusion of pregnancy before starting treatment
- Constant medical supervision and monitoring for Echinococcosis treatment
Therapeutic Class
- Anthelmintic
Storage Conditions
- Keep in a dry place
- Away from light and heat
- Keep out of the reach of children