Cardocal 10 mg (Tablet)
Unit Price: ৳ 9.00 (3 x 10: ৳ 270.00)
Strip Price: ৳ 90.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Cilnidipine |
| Company | Beximco pharmaceuticals ltd |
| Also available as |
Title and Category
- Cardocal medicine
- Hypertension management medication
- Calcium-channel blocker
Indications
- Manages hypertension for end-organ protection
- Useful in elderly patients
- Useful in patients with diabetes and albuminuria
- Used in patients with chronic kidney disease
Pharmacology
- Cilnidipine is a dihydropyridine calcium-channel blocker
- Binds to dihydropyridine binding sites of L-type voltage dependent calcium channel
- Inhibits Ca2+ influx across cell membranes
- Causes vasodilation and vascular smooth muscle relaxation
- Inhibits Ca2+ influx via N-type voltage dependent calcium channels
Dosage and Administration
- Adult dose: 5-10 mg once daily after breakfast
- Maximum adult dose: 20 mg once daily
- Pediatric use safety not established
- Elderly use: initiate therapy with lowest possible dose (5 mg)
Interactions
- Interacts with other antihypertensive medications
- Interacts with antipsychotics causing hypotension
- Interacts with quinidine, carbamazepine, phenytoin, rifampicin, cimetidine, and erythromycin
Contraindications
- Contraindicated in patients with known sensitivity to Cilnidipine or excipients
- Contraindicated in patients with cardiogenic shock, recent MI, acute unstable angina, and severe aortic stenosis
Side Effects
- Common side effects include dizziness, flushing, headache, hypotension, peripheral oedema, palpitations, GI disturbances, increased micturition frequency, lethargy, eye pain, and depression
Pregnancy and Lactation
- Not to be administered in pregnant women
- Avoid administration in nursing mothers
- Discontinue lactation if administration is indispensable
Precautions and Warnings
- Administer with care in patients with serious hepatic dysfunction
- Administer with care in patients with history of serious adverse reactions to calcium antagonists
- Gradually decrease dosage during discontinuation under close observation
Therapeutic Class
- Belongs to the calcium-channel blockers therapeutic class
Storage Conditions
- Store below 30°C
- Protect from light and moisture
- Keep away from reach out of the children