Cilmedip 10 mg (Tablet)
Unit Price: ৳ 6.00 (3 x 10: ৳ 180.00)
Strip Price: ৳ 60.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Cilnidipine |
| Company | Ibn sina pharmaceuticals ltd |
| Also available as |
Indications
- Management of hypertension for end-organ protection
- Useful for elderly patients
- Useful for patients with diabetes and albuminuria
- Useful for patients with chronic kidney disease
Pharmacology
- Dihydropyridine calcium-channel blocker
- Binds to dihydropyridine binding sites of L-type voltage dependent calcium channel
- Inhibits Ca^2^ influx across cell membranes of vascular smooth muscle cells
- Causes vasodilation
- Inhibits Ca^2^ influx via N-type voltage dependent calcium channels in sympathetic nerve cell membrane
- Inhibits release of norepinephrine from sympathetic nerve terminals
- Suppresses reflex increase in heart rate after blood pressure reduction
Dosage & Administration
- Adult dosage: 5-10 mg once daily after breakfast
- Maximum adult dose: 20 mg once daily
- Pediatric use safety not established
- Elderly use: initiate therapy with lowest possible dose (5 mg)
Interaction
- Interacts with other anti-hypertensive drugs
- Interacts with antipsychotics causing hypotension
- Interacts with quinidine, carbamazepine, phenytoin, rifampicin, cimetidine, erythromycin
Contraindications
- Contraindicated in patients with known sensitivity to Cilnidipine or any excipients
- Contraindicated in patients having cardiogenic shock, recent MI or acute unstable angina
- Contraindicated in patients with severe aortic stenosis
Side Effects
- Dizziness
- Flushing
- Headache
- Hypotension
- Peripheral edema
- Palpitations
- GI disturbances
- Increased micturition frequency
- Lethargy
- Eye pain
- Depression
Pregnancy & Lactation
- Should not be administered in pregnant women or women with possibilities of being pregnant
- Avoid administration to nursing mothers
- If administration is indispensable, instruct patient to discontinue lactation
Precautions & Warnings
- Administer with care in patients with serious hepatic dysfunction
- Administer with care in patients with history of serious adverse reactions to calcium antagonists
- Gradually decrease dosage during discontinuation under close observation
Therapeutic Class
- Calcium-channel blockers
Storage Conditions
- Store below 30°C
- Protect from light and moisture
- Keep away from reach of children