Oxcarb XR 150 mg (Tablet (Extended Release))

Indications

• Monotherapy in the treatment of partial seizures for adults
• Adjunctive therapy in the treatment of partial seizures for adults and pediatrics
• Monotherapy in the treatment of partial seizures in children 4-16 years
• Adjunctive therapy in the treatment of partial seizures in children 2-16 years

Pharmacology

• Mechanism of action involving blockade of voltage-sensitive sodium channels
• Exerted primarily through the metabolite derivative (MHD) of Oxcarbazepine
• Stabilization of hyper excited neural membranes
• Inhibition of repetitive neuronal firing

Dosage & Administration

• Recommended initial dose for adults: 600 mg/day given twice a day
• Maximum daily dose for adults: 2400 mg/day
• Dependent pediatric dose based on weight
• For pediatric patients aged 2 to <4 years and under 20 kg, starting dose of 16 to 20 mg/kg/day may be considered
• Specific dosage adjustments for patients with creatinine clearance <30 mL/min

Interaction

• Inhibition of the CYP2C19 enzyme by Oxcarb XR and its metabolite
• Potential interactions with medications metabolized by CYP2C19
• Reduced effectiveness of certain hormonal contraceptives
• Altered AUC and bioavailability of concomitant medications

Contraindications

• Hypersensitivity to the active substance or any of the excipients

Side Effects

• Common adverse reactions: somnolence, headache, dizziness, nausea, fatigue
• Rare occurrence of clinically significant hyponatremia
• Reports of class I hypersensitivity reactions including rash, pruritus, urticaria, and angioedema

Pregnancy & Lactation

• Potential to cause serious birth defects and bleeding disorders during pregnancy
• Administration of vitamin K1 as a preventive measure in the last few weeks of pregnancy
• Excretion of Oxcarbazepine and its active metabolite in human breast milk

Precautions & Warnings

• Caution advised when combining with alcohol due to possible additive sedative effect
• Recommendation for gradual withdrawal to minimize potential increased seizure frequency

Therapeutic Class

• Adjunct anti-epileptic drugs

Related Brands

• Oxcarb XR 600 mg (Tablet (Extended Release)) - renata-limited
• Oxcarb XR 300 mg (Tablet (Extended Release)) - renata-limited