Oxcarb XR 300 mg (Tablet (Extended Release))

Indications

• Monotherapy in the treatment of partial seizures in adults
• Adjunctive therapy in the treatment of partial seizures in adults
• Monotherapy in the treatment of partial seizures in children aged 4-16 years
• Adjunctive therapy in the treatment of partial seizures in children aged 2-16 years

Pharmacology

• Mechanism of action based on blockade of voltage-sensitive sodium channels
• Stabilization of hyper excited neural membranes
• Inhibition of repetitive neuronal firing
• Diminishment of propagation of synaptic impulses

Dosage & Administration

• Initial dose for adults: 600 mg/day, given twice-a-day
• Maximum daily dose for adults: 1200-2400 mg/day
• Initiation dose for pediatrics: 8 to 10 mg/kg/day, given twice-a-day
• Maximum maintenance dose for pediatrics: dependent upon patient weight

Interaction

• Inhibition of the enzyme CYP2C19
• Potential interactions with antiepileptic drugs metabolised by CYP2C19
• Interactions with hormonal contraceptives
• Effect on AUC of felodipine
• Decrease in bioavailability of MHD with verapamil

Contraindications

• Hypersensitivity to the active substance or any excipients

Side Effects

• Common adverse reactions: somnolence, headache, dizziness, diplopia, nausea, vomiting, fatigue
• Rare occurrence of hyponatremia
• Reports of class I hypersensitivity reactions including rash, pruritus, urticaria, angioedema, anaphylaxis

Pregnancy & Lactation

• Potential to cause serious birth defects
• Risk of bleeding disorders in newborns
• Precautionary use of vitamin K1 in the last weeks of pregnancy and in the newborn
• Excretion of Oxcarbazepine and its metabolite in breast milk, cautionary advice for breastfeeding

Precautions & Warnings

• Caution with alcohol consumption during therapy
• Gradual withdrawal to minimize potential of increased seizure frequency

Therapeutic Class

• Adjunct anti-epileptic drugs

Related Brands

• Oxcarb XR 600 mg (Tablet (Extended Release)) - renata-limited