Pneumoclar 125 mg/5 ml (Powder for Suspension)
60 ml bottle: ৳ 380.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Clarithromycin |
| Company | Dbl pharmaceuticals ltd |
Indications
- Treatment of acute bacterial exacerbation of chronic bronchitis in adults
- Treatment of acute maxillary sinusitis
- Treatment of community-acquired pneumonia
- Treatment of pharyngitis or tonsillitis
- Treatment of uncomplicated skin and skin structure infections
- Treatment of acute otitis media in pediatric patients
- Treatment and prophylaxis of disseminated mycobacterial infections
- Treatment of Helicobacter pylori infection and duodenal ulcer disease in adults
Pharmacology
- Inhibits microsomal protein synthesis in susceptible organisms
- Binds to donor site on 50S subunit of bacterial ribosome
- Prevents translocation to the donor site
- Active against most Gram-positive bacteria, Chlamydia, some Gram-negative bacteria and Mycoplasmas
Dosage & Administration
- Dosage for acute bacterial exacerbation of chronic bronchitis in adults
- Dosage for acute maxillary sinusitis in adults
- Dosage for community-acquired pneumonia in adults
- Dosage for pharyngitis or tonsillitis in adults
- Dosage for uncomplicated skin and skin structure infections in adults
- Dosage for treatment and prophylaxis of disseminated Mycobacterium avium disease in adults
- Dosage for Helicobacter pylori infection and duodenal ulcer disease in adults
- Combination dosing regimens for H. pylori infection
- Dosage for mycobacterial infections in pediatric patients
- Recommended dosage in renal and hepatic impairment
Interaction
- Contraindicated with HMG-CoA reductase inhibitors
- Contraindicated with gastroprokinetic agents
- Contraindicated with ergot alkaloids
- Contraindicated with antipsychotics
- Contraindicated with anti-gout agents
- Not recommended with antiarrhythmics drugs
Contraindications
- Known hypersensitivity to clarithromycin or erythromycin
- History of cholestatic jaundice or hepatic dysfunction associated with prior use of clarithromycin
Side Effects
- Nausea
- Vomiting
- Diarrhoea
- Abdominal pain
- Stomatitis
- Glossitis
- Headache
- Allergic reactions
- Taste perversion
- Transient central nervous system side effects
Pregnancy & Lactation
- Use in neonates and children
- Caution regarding breast milk from mothers receiving Clarithromycin
Precautions & Warnings
- Discontinue if severe acute hypersensitivity reactions occur
- Avoid in patients with known QT prolongation
- Avoid in patients receiving drugs known to prolong the QT interval
- Discontinue if signs and symptoms of hepatitis occur
- Increased risk of all-cause mortality in patients with coronary artery disease
Use in Special Populations
- Safety and effectiveness in pediatric patients 6 months and older
- Safety and effectiveness in pediatric patients 20 months and older with advanced HIV infection
Overdose Effects
- Ingestion of large amounts can produce gastro-intestinal symptoms
- Adverse reactions accompanying overdosage should be treated promptly
Therapeutic Class
- Macrolides
Storage Conditions
- Store in a cool and dry place
- Protected from light & moisture
- Reconstituted suspension must be used within 7 days at room temperature
- Reconstituted suspension must be used within 14 days when stored in a refrigerator
- Keep out of reach of children