Diablo 500 mg (Tablet)

Unit Price: ৳ 4.00 (3 x 10: ৳ 120.00)

Strip Price: ৳ 40.00

Medicine Details

Diablo Tablet is used for the management of type 2 diabetes mellitus in adults, children from 10 years of age, and adolescents. It helps in controlling postprandial plasma glucose, improving insulin sensitivity, and reducing diabetic complications in overweight patients.

Treatment of type 2 diabetes mellitus in overweight patients when dietary management and exercise alone does not result in adequate glycaemic control
Monotherapy or in combination with other oral antidiabetic agents or insulin in adults
Monotherapy or in combination with insulin in children from 10 years of age and adolescents
Reduction of diabetic complications in overweight type 2 diabetic adult patients treated with metformin as first-line therapy after diet failure

Metformin is a biguanide type oral antihyperglycemic drug used in the management of type 2 diabetes
Lowers both basal and postprandial plasma glucose
Decreases hepatic glucose production, intestinal absorption of glucose, and improves insulin sensitivity

Dosage must be individualized based on effectiveness and tolerance, not exceeding the maximum recommended daily doses
Adult starting dose: 500 mg twice a day or 850 mg once a day, dosage increases made in increments of 500 mg weekly or 850 mg every 2 weeks, up to a total of 2000 mg per day
Children starting dose: 500 mg twice a day, dosage increases made in increments of 500 mg weekly up to a maximum of 2000 mg per day
Dosage of Metformin XR for adults: 500 mg once daily with the evening meal, dose increased in increments of 500 mg weekly, up to a maximum of 2000 mg once daily with the evening meal

No information available about chronic co-administration with Furosemide
Nifedipine may enhance the absorption of Diablo
Cationic drugs have the potential for interaction with Diablo by competing for common renal tubular transport systems
Certain drugs tend to produce hyperglycemia and may lead to loss of glycemic control

Hypersensitivity to the active substance or to any of the excipients
Acute metabolic acidosis, severe renal failure, acute conditions altering renal function, conditions causing tissue hypoxia
Acute or chronic diseases causing tissue hypoxia, dehydration, severe infection, shock

Hemolytic anemia
Lactic acidosis (rare)
Peripheral neuropathy in patients with vitamin B12 deficiency
Taste disturbance, encephalopathy
Gastrointestinal disorders such as nausea, vomiting, diarrhea, abdominal pain, and loss of appetite
Liver function test abnormalities or hepatitis (very rare)
Skin reactions such as erythema, pruritus, urticaria (very rare)

Uncontrolled diabetes during pregnancy associated with increased risk of congenital abnormalities and perinatal mortality. Insulin is recommended during pregnancy
Metformin excreted into human breast milk, breastfeeding not recommended during metformin treatment

Substantial excretion by the kidney, risk of accumulation and lactic acidosis increases with impaired renal function
May lower vitamin B12 level, increases risk of hypoglycemia when used in combination with insulin or insulin secretagogue
Regular monitoring of renal function advised for all diabetics, metformin therapy should be stopped before surgery and reinstated only after renal function is regained

Elderly subjects: potential for decreased renal function, dosage adjustment necessary based on renal function
Diagnosis of type 2 diabetes mellitus should be confirmed before treatment with metformin is initiated, no long-term data on effect on growth and puberty available
Particular caution recommended when prescribing to children aged between 10 and 12 years
Creatinine clearance should be determined before treatment initiation, GFR assessment before and regularly during treatment
Contraindicated in patients with GFR <30 ml/min

Hypoglycemia not seen with Diablo doses up to 85 gm, lactic acidosis has occurred in such circumstances
Lactic acidosis is a medical emergency and must be treated in hospital
Hemodialysis is the most effective method to remove lactate and Diablo