Pazoren 200 mg (Tablet)
Unit Price: ৳ 350.00 (2 x 6: ৳ 4,200.00)
Strip Price: ৳ 2,100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Pazopanib hydrochloride |
| Company | Renata limited |
Indications
- treatment of advanced renal cell carcinoma
- treatment of advanced soft tissue sarcoma
- patient eligibility for treatment with Pazoren
- efficacy of Pazoren for adipocytic STS
- efficacy of Pazoren for gastrointestinal stromal tumors
Pharmacology
- Pazopanib as a multi-tyrosine kinase inhibitor
- inhibition of VEGFR and PDGFR
- binding of Pazopanib to human plasma protein
- metabolism of Pazopanib by CYP3A4
- elimination of Pazopanib from the body
Dosage & Administration
- recommended starting dose of Pazopanib
- administration without food
- dose not to exceed 800 mg
- effect of missed dose on administration
Interaction
- inhibition or induction of Cytochrome P450 3A4 Enzymes
- CYP3A4 Inhibitors
- CYP3A4 Inducers
- Effects of Pazoren on CYP Substrates
- interaction with transporters
Contraindications
- contraindication in case of hypersensitivity
Side Effects
- Hepatic Toxicity and Hepatic Impairment
- QT Prolongation and Torsades de Pointes
- Cardiac Dysfunction
- Hemorrhagic Events
- Arterial and Venous Thromboembolic Events
Pregnancy & Lactation
- potential fetal harm from Pazopanib
- advice for pregnant women and women
Precautions & Warnings
- Hepatic Toxicity and Hepatic Impairment
- QT Prolongation and Torsades De Pointes
Use in Special Populations
- use of contraception in females during treatment
- use of condoms in males during treatment
- lack of established safety in pediatric use
Overdose Effects
- evaluation of Pazoren doses in clinical trials
- observation of dose-limiting toxicity
- treatment of overdose and lack of specific antidote
Storage Conditions
- storage temperature and conditions
- protection from sunlight
- keeping out of reach of children