Olixar 20 mg (Tablet)
Unit Price: ৳ 8.00 (3 x 10: ৳ 240.00)
Strip Price: ৳ 80.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Olanzapine |
| Company | Everest pharmaceuticals ltd |
| Also available as |
Indications
- Acute and maintenance treatment of schizophrenia
- Treatment of related psychoses
- Treatment of positive symptoms like delusions and hallucinations
- Treatment of negative symptoms like emotional and social withdrawal
- Treatment of acute manic or mixed episodes in bipolar disorder
Pharmacology
- Affinities for serotonin and dopamine receptors
- Mechanism of action unknown
- Well absorbed after oral administration
- Reaches peak plasma concentrations within 5 to 8 hours
Dosage
- Initial dose of 5-10 mg once daily
- Daily dosage adjustment within the range of 5-20 mg daily
- Maximum dose of 20 mg daily
Administration
- Can be given without regard to meals
- Gradual tapering of the dose should be considered while discontinuing
Interaction
- May antagonize the effects of levodopa and dopamine agonists
- May be affected by drugs that induce CYP1A2 or glucuronidation enzymes
- Inhibitors of CYP1A2 may potentially inhibit elimination
- Carbamazepine may increase clearance
- Concomitant administration of activated charcoal reduces oral bioavailability
- Caution should be taken when administered with centrally acting drugs and alcohol
Contraindications
- Known hypersensitivity to any ingredient
- Known risk for narrow-angle glaucoma
Side Effects
- Very common undesirable effects include somnolence and weight gain
- Other effects may include increased appetite, elevated glucose and triglyceride levels, dizziness, akathisia, and more
Pregnancy & Lactation
- Use in pregnancy only if potential benefits justify potential risk to the fetus
- No reports to show teratogenicity
- Patients should not breastfeed while taking
Precautions & Warnings
- Use cautiously in patients with a history of seizures
- Use cautiously in patients with low leukocyte and/or neutrophil counts
- Use cautiously in patients with impaired hepatic function
- Caution patients about operating hazardous machinery
Use in Special Populations
- Not studied in subjects under 18 years of age
- Starting dose for elderly patients (65 and over) is 5 mg/day
- Starting dose for patients with hepatic or renal impairment is 5 mg/day
Therapeutic Class
- Atypical neuroleptic drugs
Storage Conditions
- Keep below 30°C temperature
- Away from light and moisture
- Keep out of the reach of children