Olay 10 mg (Tablet)
Unit Price: ৳ 4.50 (50's pack: ৳ 225.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Olanzapine |
| Company | The white horse pharmaceuticals ltd |
| Also available as |
Indications
- Acute and maintenance treatment of schizophrenia and related psychoses
- Treatment of acute manic or mixed episodes in bipolar disorder
Pharmacology
- Affinities for serotonin 5HT2A/2C, 5HT3, 5HT6; dopamine D1, D2, D3, D4, D5; cholinergic muscarinic receptors M1-M5; α1 adrenergic; and histamine H1 receptors
- Mechanism of action is unknown
- Efficacy in schizophrenia is mediated through a combination of dopamine and serotonin type 2 (5HT2) antagonism
- Well absorbed after oral administration
- Reaching peak plasma concentrations within 5 to 8 hours
- Absorption not affected by food
- Not mutagenic or clastogenic
- Not carcinogenic
Dosage
- Initial dose is 5-10 mg once daily for schizophrenia and bipolar disorder
- Daily dosage may be adjusted within the range of 5-20 mg daily
- Maximum dose is 20 mg daily
- Initial dose is 15 mg once daily for monotherapy for mania
Administration
- Can be given without regard to meals
- Gradual tapering of the dose should be considered while discontinuing
Interaction
- May antagonize the effects of levodopa and dopamine agonists
- Drugs that induce CYP1A2 or glucuronidation enzymes may increase clearance
- Inhibitors of CYP1A2 may potentially inhibit elimination
- Carbamazepine may increase clearance
- Concomitant administration of activated charcoal reduces oral bioavailability by 50-60%
- Caution should be taken when administered with centrally acting drugs and alcohol
Contraindications
- Known hypersensitivity to any ingredient
- Known risk for narrow-angle glaucoma
Side Effects
- Very common undesirable effects such as somnolence and weight gain
- Increased appetite, elevated glucose and triglyceride levels, dizziness, akathisia, Parkinson's disease, dyskinesia, orthostatic hypotension, anticholinergic effects, asthenia, edema, photosensitivity reaction
Pregnancy & Lactation
- Should be used in pregnancy only if potential benefits justify potential risk to the fetus
- No report showing teratogenicity
- Patients should not breastfeed while taking
Precautions & Warnings
- Should be used cautiously in patients with history of seizures, low leukocyte and/or neutrophil counts, conditions associated with seizures, drug-induced bone marrow depression/toxicity, impaired hepatic function, using hepatotoxic medicines, centrally acting drugs, and medicines known to increase QT interval
- Patients should be cautioned about operating hazardous machinery, including motor vehicles
Use in Special Populations
- Not studied in subjects under 18 years of age
- Starting dose for elderly patients (age 65 and over) is 5 mg/day
- Starting dose for patients with hepatic or renal impairment is 5 mg/day
Therapeutic Class
- Atypical neuroleptic drugs
Storage Conditions
- Keep below 30°C temperature
- Away from light and moisture
- Keep out of the reach of children