Enclot 500 mg/5 ml (IM/IV Injection)

5 ml ampoule: ৳ 50.19 (1 x 5: ৳ 250.95)

Medicine Details

Category Details
Generic Tranexamic acid
Company Opsonin pharma ltd
Also available as
Enclot 500 mg capsule Enclot 250 mg capsule

Indications

  • Prophylaxis and therapy of hemophtoes
  • Digestive hemorrhages
  • Hemorrhagic syndromes in leukaemia
  • Cirrhosis and hemophilia
  • Thrombocytopenic purpura
  • Accidents during thrombolytic therapy and transfusion
  • Prophylaxis and antihemorrhagic therapy during operations of any type and nature
  • Prophylaxis and antihemorrhagic therapy of prostatic, vesical and renal surgery
  • Prophylaxis and therapy of post-partum and puerperium hemorrhages
  • Hematurias
  • Prophylaxis and antihemorrhagic therapy during a tonsillectomy
  • Prophylaxis and antihemorrhagic therapy during maxillofacial operations
  • Supportive therapy in oncology

Pharmacology

  • Preparation of tranexamic acid
  • Strong antifibrinolytic action
  • Inhibition of plasminogen activation
  • Low acute and chronic toxicity
  • Well absorbed by oral route
  • Excreted mainly by renal route
  • Does not interfere with clotting processes
  • No tendency to thrombophilia

Dosage & Administration

  • Usual dose for adults: 500-1000 mg 3 times daily
  • Mean recommended daily doses for prophylaxis: 0.5-1 gm orally, 500 mg by the parenteral route
  • For therapy of hemorrhagic manifestations: the oral dose increases to 1-3 gm given in divided doses
  • For every kg of body weight from 5-10 mg are orally administered daily in divided doses for children
  • Elderly patients: No reduction in dosage is necessary unless there is evidence of renal failure

Interaction

  • Incompatible with solutions containing penicillins
  • Antagonistic interaction with thrombolytic drugs like Streptokinase & Urokinase
  • Potential for increased thrombus formation by concomitant administration of estrogen containing drugs
  • Avoid direct admixture with whole blood during transfusion

Contraindications

  • Known individual hypersensitivity to the product
  • Thromboembolic disease
  • Arterial and venous thrombosis
  • Endocavitary hemorrhages
  • Serious kidney failure

Side Effects

  • Sense of fatigue
  • Conjunctival irritation
  • Nasal blockage
  • Itching
  • Skin reddening
  • Exanthems
  • Nausea
  • Diarrhea
  • Gastric pyrosis
  • Postural hypotension

Pregnancy & Lactation

  • Tranexamic Acid should not be administered during known and presumed pregnancy
  • Passes into breast milk to a concentration of approximately one hundredth of the concentration in the maternal blood
  • Unlikely antifibrinolytic effect in the infant

Precautions & Warnings

  • Use in cases of hyperfibrinolysis
  • Begin prophylactic treatment 24 hours before operation and continue for 3-4 days after it
  • Prolong therapy of hemorrhages for at least 24 hours after manifestations have disappeared
  • Reduce doses in hematuria to prevent formation of clots in the urinary tract
  • Avoid use in serious renal insufficiency or anuric syndromes
  • Use with caution in less serious renal dysfunctions
  • Particular care required in cardiopathic and hepatopathic subjects

Therapeutic Class

  • Anti-fibrinolytic drugs
  • Haemostatic drugs

Storage Conditions

  • Store in a dry place at 15-30°C
  • Away from light
  • Keep out of children's reach

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