Veneta 50 mg (Tablet)

Unit Price: ৳ 210.00 (3 x 10: ৳ 6,300.00)
Strip Price: ৳ 2,100.00

Medicine Details

Category Details
Generic Venetoclax
Company Drug international ltd
Also available as
Veneta 100 mg tablet Veneta 10 mg tablet

Indications

  • Treatment of chronic lymphocytic leukemia (CLL)
  • Indicated for adult patients
  • Indicated for patients with 17p deletion or TP53 mutation
  • Indicated for patients who have failed chemoimmunotherapy and B-cell receptor pathway inhibitor

Pharmacology

  • Selective and orally bioavailable small-molecule BCL-2 inhibitor
  • Restores apoptosis process by binding to BCL-2 protein
  • Triggers mitochondrial outer membrane permeabilization

Dosage & Administration

  • Starting dose of 20mg Venetoclax once daily for 7 days
  • Gradual increase to a daily dose of 400mg over 5 weeks
  • 400mg once daily for 24 months in combination with Rituximab
  • Treatment continued until disease progression or intolerance

Interaction

  • CYP3A inhibitors
  • CYP3A inducers
  • P-gp and BCRP inhibitors
  • Contraindicated with strong CYP3A inhibitors
  • Avoid use with moderate CYP3A inhibitors
  • Need dose reduction with concomitant strong CYP3A inhibitors

Contraindications

  • Hypersensitivity to active substance or excipients
  • Concomitant use of strong CYP3A inhibitors
  • Concomitant use of St. John's wort preparations

Side Effects

  • Neutropenia
  • Diarrhoea
  • Upper respiratory tract infection
  • Anaemia
  • Fatigue
  • Serious side effects

Pregnancy & Lactation

  • Avoid pregnancy during treatment and for 30 days after
  • Unknown effect on hormonal contraceptives
  • Embryo-foetal toxicity
  • Breast-feeding not recommended
  • Potential effect on male fertility

Precautions & Warnings

  • Tumour lysis syndrome risks
  • Neutropenia monitoring
  • Immunization precautions
  • Avoidance of live vaccines
  • Limitations with CYP3A inducers
  • Contraceptive requirements for women of childbearing potential

Use in Special Populations

  • Elderly patients dosing
  • Renal impairment dosing
  • Hepatic impairment dosing
  • No safety data in pediatric population

Overdose Effects

  • No specific antidote available
  • Need for close monitoring and supportive treatment
  • Special attention during dose-titration phase

Therapeutic Class

  • Cytotoxic Chemotherapy

Storage Conditions

  • Store below 30°C
  • Keep out of reach of children
  • Protect from moisture and light

Related Brands