Palboxen 125 mg (Capsule)
Unit Price: ৳ 400.00 (1 x 21: ৳ 8,400.00)
Strip Price: ৳ 8,400.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Palbociclib |
| Company | Everest pharmaceuticals ltd |
Indications
- Kinase inhibitor
- HR-positive breast cancer treatment
- HER2-negative breast cancer treatment
- Combination therapy
- Aromatase inhibitor therapy
- Fulvestrant therapy
Pharmacology
- Cyclin-dependent kinase 4/6 inhibitor
- Cellular proliferation inhibition
- Estrogen receptor-positive breast cancer treatment
- Retinoblastoma protein phosphorylation reduction
- E2F expression reduction
- Cell senescence induction
- Tumor growth inhibition
Dosage & Administration
- 125 mg capsule
- Oral administration
- Once daily dosing
- 21 days on, 7 days off cycle
- Administration with food
- Dose modification for adverse reactions
- LHRH agonist consideration for men
Interaction
- Metabolized by CYP3A and SULT enzymes
- Time-dependent CYP3A inhibitor
- CYP3A-inhibitor effects
- CYP3A inducer effects
- Plasma concentration alterations with other drugs
Side Effects
- Decreased blood cell count
- Infections
- Liver enzyme level increase
- Fatigue
- Nausea
- Hair loss
- Mouth and lips inflammation
- Diarrhea
- Anemia
- Rash
- Weakness/lethargy
- Vomiting
- Dry skin
- Fever
Pregnancy & Lactation
- Fetal harm risk
- Adverse pregnancy outcomes
- Risk percentages for birth defects and miscarriage
Precautions & Warnings
- Neutropenia
- Neutrophil counts monitoring
- Dose adjustment for neutropenia
- Febrile neutropenia risk
- Interstitial lung disease/pneumonitis risk
- Embryo-fetal toxicity
- Contraception recommendation for females of reproductive potential
Overdose Effects
- No known antidote
- General supportive measures for overdose
Therapeutic Class
- Protein kinase inhibitor
Storage Conditions
- Below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children