Thyronor 100 mcg (Tablet)
Unit Price: ৳ 3.10 (3 x 35: ৳ 325.00)
Strip Price: ৳ 108.33
Medicine Details
| Category | Details |
|---|---|
| Generic | Levothyroxine sodium |
| Company | Nuvista pharma ltd |
| Also available as |
Indications
- Replacement therapy in hypothyroidism of any etiology
- Suppression of Thyroid Stimulating Hormone (TSH) levels in presence of goitres and nodules
- Suppression of goitrogenic effects of other drugs
- Diagnostic aid in suppression tests
Pharmacology
- Contains synthetic Levothyroxine (T4)
- Identical to natural hormone T4 produced in Thyroid gland
- About 30% of T4 is converted to more active Triiodothyronine (T3)
- TBG (Thyroxine Binding Globulin) is major carrier of T4
- Half-life of elimination of T4 is 6 to 7 days
- Liver is major site of degradation of Thyroid hormones
- Enterohepatic circulation of the Thyroid hormones
Dosage & Administration
- Initial starting dose: 25-50 mcg/day
- Gradual increments in dose at 6-8 week intervals
- Severe hypothyroidism: Initial dose is 12.5-25 mcg/day
- Pediatric Dosage (Newborns): 10-15 mcg/kg/day
- Pediatric Dosage (Infants and Children): Varies with age
- Dose adjustment based on clinical response and laboratory parameters
Interaction
- Concurrent use of tri/tetracyclic antidepressants may increase therapeutic and toxic effects
- Addition of Thyronor to antidiabetic or insulin therapy may result in increased requirements
Contraindications
- Untreated subclinical or overt Thyrotoxicosis
- Acute Myocardial Infarction
- Uncorrected Adrenal failure
Side Effects
- Adverse reactions associated with Thyronor therapy
- Primarily those of hyperthyroidism due to therapeutic overdose
- Includes symptoms in multiple body systems
Pregnancy & Lactation
- Pregnancy Category A
- Levothyroxine requirements may increase during pregnancy
- Caution recommended during nursing
Precautions & Warnings
- Adrenocortical insufficiency may be present in patients with hypothyroidism due to pituitary gland function decrease
- Great care needed in patients with cardiovascular disease and/or severe and long-existing hypothyroidism
- Dosage adjustment required with marked change of body weight
- Monitoring of blood levels of T3 and T4
Overdose Effects
- Signs and symptoms of overdose are those of hyperthyroidism
- Treatment is symptomatic
Therapeutic Class
- Thyroid drugs & hormone
Storage Conditions
- Store below 30°C and dry place
- Protect from light
- Keep out of the reach of children