Gaba-P CR 82.5 mg (Tablet (Controlled Release))
Medicine Details
| Category | Details |
|---|---|
| Generic | Pregabalin |
| Company | Renata limited |
| Also available as |
Indications
- Neuropathic pain associated with diabetic peripheral neuropathy (DPN)
- Postherpetic neuralgia (PHN)
- Adjunctive therapy for the treatment of partial-onset seizures in patients 1 month of age and older
- Fibromyalgia
- Neuropathic pain associated with spinal cord injury
Pharmacology
Pregabalin is a structural derivative of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). It does not bind directly to GABA receptors, but binds with high affinity to the alpha2-delta site in central nervous system tissues, involved in anti-nociceptive and antiseizure effects.
Maximum Recommended Dose
330 mg/day for adults with neuropathic pain associated with diabetic peripheral neuropathy
Recommended Dosage for Postherpetic Neuralgia in Adults
75 to 150 mg two times a day or 50 to 100 mg three times a day (150 to 300 mg/day)
Recommended Dosage for Fibromyalgia in Adults
300 to 450 mg/day
Recommended Dosage for Neuropathic Pain Associated with Spinal Cord Injury in Adults
150 to 600 mg/day
Route of Administration
Oral, can be taken with or without food
Pregnancy & Lactation
Pregabalin is not recommended during pregnancy and breastfeeding due to potential risk to the fetus and presence in the milk of lactating women
Precautions
- Angioedema may occur and require immediate discontinuation
- Increased risk of suicidal thoughts or behavior
- Respiratory depression may occur when used with concomitant CNS depressants
- May cause dizziness and somnolence, impairing the ability to drive or operate machinery
- Caution should be exercised when coadministering with antidiabetic agents
- Discontinuation should be gradual over a minimum of 1 week
Use in Special Populations
Safety and effectiveness in pediatric patients have not been established for certain uses
Overdose Effects
- Reduced consciousness
- Depression/anxiety
- Confusional state
- Agitation and restlessness
- Seizures and heart block
- No specific antidote, general supportive care indicated
Therapeutic Class
Adjunct anti-epileptic drugs, Primary anti-epileptic drugs
Storage Conditions
Keep in a cool & dry place (below 30°C), protected from light & moisture
Chemical Structure
- Molecular Formula: C8H17NO2
- Chemical Structure Image: https://medex.com.bd/storage/res/g-res-919-pregabalin-chemical-structure-dKjKzfuVRrNkwNMBalNK.svg
Common Questions about Gaba-P CR 82.5 mg Tablet
- What is Gaba-P CR 82.5 mg CR Tablet?: An anticonvulsant considered first-line treatment for neuropathic pain, shingles, seizures, and fibromyalgia
- How long do I need to use Gaba-P CR 82.5 mg CR Tablet before I see improvement in my condition?: Until improvement is observed
- At what frequency do I need to use Gaba-P CR 82.5 mg CR Tablet?: As prescribed by the doctor
- Should I use Gaba-P CR 82.5 mg CR Tablet empty stomach, before food or after food?: After food in a prescribed dosage
- What are the instructions for the storage and disposal of Gaba-P CR 82.5 mg CR Tablet?: To be kept in a cool dry place and in its original packaging, out of reach of children and pets
- Does Gaba-P CR 82.5 mg CR Tablet work in the same way for each disease?: No, it works differently for different diseases
- How long do I need to take Gaba-P CR 82.5 mg CR Tablet?: Duration depends on the condition, consult the doctor
- Is it necessary to continue taking Gaba-P CR 82.5 mg CR Tablet even if I feel fine?: Yes, do not stop without doctor's consultation
- Can I take Diazepam and Gaba-P CR 82.5 mg CR Tablet together?: Yes, they can be used together
- Can the use of Gaba-P CR 82.5 mg CR Tablet cause weight gain?: Yes, it may cause weight gain, consult a dietician for concerns