Diampa M 5 mg+500 mg (Tablet)
Unit Price: ৳ 18.00 (3 x 6: ৳ 324.00)
Strip Price: ৳ 108.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Empagliflozin metformin hydrochloride |
| Company | Renata limited |
Indications
- Treatment of type 2 diabetes mellitus
- Adjunct to diet and exercise
- Insufficiently controlled on Metformin alone
- Combination therapy for diabetes management
- Use in combination with Empagliflozin and Metformin
- Adult use only
Pharmacology
- Inhibitor of Sodium-Glucose Co-Transporter 2 (SGLT2)
- Reduces renal reabsorption of glucose
- Lowers renal threshold for glucose
- Increases urinary glucose excretion
- Oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Improves insulin sensitivity
Dosage & Administration
- Twice daily with meals
- Individualized dosage based on effectiveness and tolerability
- Gradual dose escalation to reduce gastrointestinal side effects
- Maximum recommended daily dose of Metformin Hydrochloride is 2000 mg and Empagliflozin is 25 mg
- Recommended individualized starting dose based on patient's current drug regimen
Interaction
- Diuretics
- Insulin or Insulin Secretagogues
- Positive Urine Glucose Test
- Drugs that Reduce Metformin Clearance
- Carbonic Anhydrase Inhibitors
- Drugs Affecting Glycemic Control
- Alcohol
Contraindications
- Hypersensitivity to Empagliflozin and Metformin
- Acute metabolic acidosis
- Diabetic pre-coma
- Severe renal failure (GFR <30 ml/min)
- Acute conditions altering renal function
- Disease causing tissue hypoxia
- Hepatic impairment
- Alcoholism
Side Effects
- Urinary tract infection
- Female genital mycotic infections
- Diarrhea
- Nausea/vomiting
- Flatulence
- Headache
- Hypoglycemia
- Vaginal moniliasis
- Thirst
- Urticaria
- Blood creatinine increased
- Diabetic ketoacidosis
Pregnancy & Lactation
- Potential risk to fetus during second and third trimesters
- Not recommended during breastfeeding
Precautions & Warnings
- Lactic Acidosis
- Hypotension
- Ketoacidosis
- Acute kidney injury & impairment in renal function
- Urosepsis, Pyelonephritis, Fournier's gangrene & Genital mycotic infections
- Hypoglycemia
- Vitamin B12 Deficiency
- Increased LDL-C
- Macrovascular Outcomes
Overdose Effects
- No toxicity at recommended doses for Empagliflozin
- Lactic acidosis in Metformin overdose
- Treatment is supportive and specific to patient's clinical status
- Haemodialysis for removal of lactate and Metformin
Therapeutic Class
- Combination Oral hypoglycemic preparations
Storage Conditions
- Keep below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children