Frabex 500 mg (Capsule)

Unit Price: ৳ 23.00 (2 x 10: ৳ 460.00)
Strip Price: ৳ 230.00

Medicine Details

Category Details
Generic Tranexamic acid
Company Square pharmaceuticals plc
Also available as
Frabex 500 mg injection

Title

  • Frabex Hemostatic Solution

Categories

  • Medicine
  • Hemostatic drugs

Description

  • Prophylaxis and therapy of various types of hemorrhages
  • Administration through oral or parenteral route
  • Low acute and chronic toxicity
  • Well absorbed by oral route
  • Excreted mainly by renal route
  • No interference with clotting processes

Color Options

  • Clear liquid

Function

  • Antifibrinolytic action
  • Inhibition of plasminogen activation
  • Prophylaxis and antihemorrhagic therapy in various medical fields

Mechanism of Action

  • Tranexamic acid as the active ingredient
  • Strong antifibrinolytic action
  • Inhibition of plasminogen activation by exogenous and endogenous activators
  • Low acute and chronic toxicity
  • Rapid onset of action (15-30 minutes after administration)
  • Excretion mainly by renal route

Dosage Forms

  • Oral solution
  • Parenteral solution

Dosage Instructions

  • Usual dose for adults: 500-1000 mg 3 times daily
  • Mean recommended daily doses for prophylaxis: 0.5-1 gm orally, 500 mg by parenteral route
  • Increased oral dose for therapy of hemorrhagic manifestations: 1-3 gm given in divided doses

Administration

  • Oral administration for adults and children
  • Parenteral administration for children
  • No reduction in dosage for elderly patients unless evidence of renal failure

Interaction

  • Incompatibility with solutions containing penicillins
  • Antagonism with thrombolytic drugs like Streptokinase & Urokinase
  • Potential increase in thrombus formation by concomitant administration with estrogen-containing drugs

Contraindications

  • Known individual hypersensitivity to the product
  • Thromboembolic disease
  • Arterial and venous thrombosis
  • Endocavitary hemorrhages
  • Serious kidney failure

Side Effects

  • Sense of fatigue
  • Conjunctival irritation
  • Nasal blockage
  • Itching
  • Skin reddening
  • Exanthems
  • Nausea
  • Diarrhea
  • Gastric pyrosis
  • Postural hypotension
  • Hypersensitivity reactions

Pregnancy & Lactation

  • Avoidance during known and presumed pregnancy
  • Passage into breast milk at low concentration unlikely to have antifibrinolytic effect in the infant

Precautions

  • Use in hyperfibrinolysis cases
  • Prophylactic treatment initiation 24 hours before operation and continued until 3-4 days after
  • Prolonged therapy of hemorrhages for at least 24 hours after manifestations have disappeared
  • Dose reduction in hematuria to prevent clot formation in urinary tract
  • Avoid use in serious renal insufficiency or anuric syndromes
  • Use with caution in less serious renal dysfunctions
  • Particular care required in cardiopathic and hepatopathic subjects

Therapeutic Class

  • Anti-fibrinolytic drugs
  • Haemostatic drugs

Storage Conditions

  • Store in a dry place at 15-30°C
  • Away from light
  • Keep out of children's reach

Related Brands