Frabex 500 mg (Capsule)
Unit Price: ৳ 23.00 (2 x 10: ৳ 460.00)
Strip Price: ৳ 230.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Tranexamic acid |
| Company | Square pharmaceuticals plc |
| Also available as |
Title
- Frabex Hemostatic Solution
Categories
- Medicine
- Hemostatic drugs
Description
- Prophylaxis and therapy of various types of hemorrhages
- Administration through oral or parenteral route
- Low acute and chronic toxicity
- Well absorbed by oral route
- Excreted mainly by renal route
- No interference with clotting processes
Color Options
- Clear liquid
Function
- Antifibrinolytic action
- Inhibition of plasminogen activation
- Prophylaxis and antihemorrhagic therapy in various medical fields
Mechanism of Action
- Tranexamic acid as the active ingredient
- Strong antifibrinolytic action
- Inhibition of plasminogen activation by exogenous and endogenous activators
- Low acute and chronic toxicity
- Rapid onset of action (15-30 minutes after administration)
- Excretion mainly by renal route
Dosage Forms
- Oral solution
- Parenteral solution
Dosage Instructions
- Usual dose for adults: 500-1000 mg 3 times daily
- Mean recommended daily doses for prophylaxis: 0.5-1 gm orally, 500 mg by parenteral route
- Increased oral dose for therapy of hemorrhagic manifestations: 1-3 gm given in divided doses
Administration
- Oral administration for adults and children
- Parenteral administration for children
- No reduction in dosage for elderly patients unless evidence of renal failure
Interaction
- Incompatibility with solutions containing penicillins
- Antagonism with thrombolytic drugs like Streptokinase & Urokinase
- Potential increase in thrombus formation by concomitant administration with estrogen-containing drugs
Contraindications
- Known individual hypersensitivity to the product
- Thromboembolic disease
- Arterial and venous thrombosis
- Endocavitary hemorrhages
- Serious kidney failure
Side Effects
- Sense of fatigue
- Conjunctival irritation
- Nasal blockage
- Itching
- Skin reddening
- Exanthems
- Nausea
- Diarrhea
- Gastric pyrosis
- Postural hypotension
- Hypersensitivity reactions
Pregnancy & Lactation
- Avoidance during known and presumed pregnancy
- Passage into breast milk at low concentration unlikely to have antifibrinolytic effect in the infant
Precautions
- Use in hyperfibrinolysis cases
- Prophylactic treatment initiation 24 hours before operation and continued until 3-4 days after
- Prolonged therapy of hemorrhages for at least 24 hours after manifestations have disappeared
- Dose reduction in hematuria to prevent clot formation in urinary tract
- Avoid use in serious renal insufficiency or anuric syndromes
- Use with caution in less serious renal dysfunctions
- Particular care required in cardiopathic and hepatopathic subjects
Therapeutic Class
- Anti-fibrinolytic drugs
- Haemostatic drugs
Storage Conditions
- Store in a dry place at 15-30°C
- Away from light
- Keep out of children's reach