Ronem 250 mg/vial (IV Injection or Infusion)

250 mg vial: ৳ 400.00

Medicine Details

Category Details
Generic Meropenem trihydrate
Company Opsonin pharma ltd
Also available as
Ronem 500 mg injection Ronem 1 gm injection

Indications

  • Pneumonia and Nosocomial Pneumonia
  • Urinary Tract Infections
  • Intra-abdominal Infections
  • Gynaecological Infections
  • Skin and Skin Structure Infections
  • Meningitis
  • Septicaemia
  • Pulmonary infections in cystic fibrosis
  • Empiric treatment for presumed infections in patients with febrile neutropenia

Pharmacology

Exerts bactericidal action by interfering with bacterial cell wall synthesis. Potent bactericidal activity against a broad spectrum of Gram-positive and Gram-negative, aerobic and anaerobic bacteria.

Dosage

  • Adults:
    • Usual dose of 500 mg to 1 gm by intravenous administration every 8 hours
    • Specific dosages for different infections: pneumonia, urinary tract infections, gynaecological infections, nosocomial pneumonias, peritonitis, intra-abdominal infections, cystic fibrosis, and meningitis
  • Children:
    • Dosage range of 10 to 40 mg/kg intravenously every 8 hours
    • Specific dosages for different infections: intra-abdominal infections, cystic fibrosis, meningitis, and febrile neutropenia
    • Instructions for children over 50 kg weight and lack of experience in children with hepatic or renal impairment

Administration

Administered by intravenous Infusion over approximately 15-30 minutes or as intravenous bolus (5 to 20 ml) over approximately 3-5 minutes

Interaction

Can be affected by Probenecid and can reduce serum valproic acid levels

Contraindications

Contraindicated in patients demonstrating hypersensitivity to the product

Side Effects

  • Inflammation
  • Thrombophlebitis
  • Pain at the site of injection
  • Skin reactions like rash, pruritus, urticaria
  • Abdominal pain
  • Nausea
  • Vomiting
  • Diarrhea
  • Headache

Pregnancy & Lactation

Pregnancy Category B. Should be used during pregnancy only if clearly needed. Caution should be exercised when administered to a nursing woman.

Precautions & Warnings

Discontinue if allergic reaction occurs. Use in patients with hepatic disease should be made with careful monitoring of transaminase and bilirubin levels.

Use in Special Populations

  • Renal impairment: Dosage should be reduced in patients with creatinine clearance less than 51 ml/min.
  • Hepatic impairment: No dosage adjustments are necessary.
  • Elderly: No dosage adjustments are necessary unless creatinine clearance is less than 51 ml/min.
  • Children: Efficacy and tolerability in infants under 3 months have not been established.

Overdose Effects

Accidental overdose could occur during therapy, particularly in patients with renal impairment. Treatment of overdose should be symptomatic.

Therapeutic Class

Other beta-lactam Antibiotics

Reconstitution

Instructions for preparation of solution for intravenous bolus and intravenous infusion administration. Compatibility with various infusion fluids.

Storage Conditions

Vial store in a cool, dry place (below 30°C), away from light & moisture. Keep out of the reach of children.

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