Frabex 500 mg/5 ml (IM/IV Injection)
5 ml ampoule: ৳ 65.00 (3 x 2: ৳ 390.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Tranexamic acid |
| Company | Square pharmaceuticals plc |
| Also available as |
Indications
- Prophylaxis of hemoptysis
- Therapy of digestive hemorrhages
- Hemorrhagic syndromes in leukemia
- Cirrhosis and hemophilia
- Thrombocytopenic purpura
- Accidents during thrombolytic therapy and transfusion
- Antihemorrhagic therapy during operations of any type and nature
- Prophylaxis and antihemorrhagic therapy of prostatic, vesical, and renal surgery
- Prophylaxis and therapy of post-partum and puerperium hemorrhages
- Hemorrhagic metropathies
- Functional menometrorrhagias
- Antihemorrhagic therapy during tonsillectomy
- Therapy during maxillofacial operations
- Promote the formation of a fibrin capsule to inhibit the growth of ovarian tumors
- Regression of ascites secondary to carcinoma
- Reduction of bleeding during surgical interventions
Pharmacology
- Strong antifibrinolytic action
- Inhibition of plasminogen activation
- Low acute toxicity
- Well absorbed by oral route
- Excretion by renal route
- No interference with clotting processes
- No tendency to thrombophilia
Dosage & Administration
- Recommended dose for adults: 500-1000 mg 3 times daily
- Mean recommended daily doses for prophylaxis: 0.5-1 gm orally, 500 mg by parenteral route
- Oral dose increases to 1-3 gm for therapy of hemorrhagic manifestations
- Orally administered daily in divided doses for children
- No reduction in dosage for elderly patients
Interaction
- Incompatible with solutions containing penicillins
- Antagonizes the antifibrinolytic action of thrombolytic drugs
- Increased potential for thrombus formation with concomitant estrogen-containing drugs
- Avoid direct admixture with whole blood during transfusion
Contraindications
- Individual hypersensitivity
- Thromboembolic disease
- Arterial and venous thrombosis
- Endocavitary hemorrhages
- Serious kidney failure
Side Effects
- Sense of fatigue
- Conjunctival irritation
- Nasal blockage
- Itching
- Skin reddening
- Exanthems
- Nausea
- Diarrhea
- Gastric pyrosis
- Postural hypotension
Pregnancy & Lactation
- Avoid during known and presumed pregnancy
- Passes into breast milk at low concentration
Precautions & Warnings
- Use in cases of hyperfibrinolysis
- Prophylactic treatment 24 hours before operation
- Prolonged therapy for at least 24 hours after manifestations have disappeared
- Care in cases of hematuria
- Avoid in serious renal insufficiency or anuric syndromes
- Use with caution in less serious renal dysfunctions
- Particular care in cardiopathic and hepatopathic subjects
Therapeutic Class
- Anti-fibrinolytic drugs
- Hemostatic drugs
Storage Conditions
- Store in a dry place at 15-30°C
- Away from light
- Keep out of children's reach