Olacent 150 mg (Tablet)
Unit Price: ৳ 350.00 (2 x 10: ৳ 7,000.00)
Strip Price: ৳ 3,500.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Olaparib |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of germline BRCA-mutated metastatic breast cancer
- Maintenance treatment for platinum sensitive relapsed ovarian cancer
Pharmacology
- PARP enzyme inhibition
- Inhibition of tumor cell growth
- DNA repair disruption
- Rapid oral absorption
- Low systemic exposure accumulation
- High protein binding
- Metabolism by CYP3A4/5
- Excretion via urine and feces
Dosage & Administration
- Oral administration
- 400 mg twice daily
- Dose adjustments for adverse reactions
- Dose modifications for CYP3A inhibitors
- Dose adjustments for renal impairment
- Pediatric use not established
Interaction
- Potentiation with myelosuppressive anticancer agents
- Effects of CYP3A inhibitors on plasma concentrations
- Effects of CYP3A inducers on plasma concentrations
Contraindications
- Hypersensitivity to Olaparib
Side Effects
- Common adverse reactions
- Discontinuation due to adverse events
- Anemia as a serious adverse reaction
Pregnancy & Lactation
- Fetal harm potential
- Potential excretion in human milk
Precautions & Warnings
- Incidence of Myelodysplastic Syndrome/Acute Myeloid Leukemia
- Pneumonitis risk
- No specific treatment for overdose
Therapeutic Class
Targeted Cancer Therapy
Storage Conditions
Store below 30°C, protect from light