Entrovas 24 mg+26 mg (Tablet)
Unit Price: ৳ 45.00 (2 x 10: ৳ 900.00)
Strip Price: ৳ 450.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Sacubitril valsartan |
| Company | Renata limited |
| Also available as |
Categories
- Cardiovascular Health
- Pediatric Medicine
Indications
- Reduction of cardiovascular death risk
- Reduction of hospitalization risk for heart failure
- Treatment of symptomatic heart failure in pediatric patients
Mode of Action
- Contains neprilysin inhibitor, sacubitril
- Contains angiotensin receptor blocker, valsartan
- Inhibits neprilysin via LBQ657
- Blocks angiotensin II type-1 receptor via valsartan
Dosage and Administration
- Starting dose of 49/51 mg orally twice daily for adults
- Starting dose varies for pediatric patients based on weight
- Titration of dose for pediatric patients
- Adjustment of dose for patients with renal or hepatic impairment
Interaction
- Dual blockade of renin-angiotensin-aldosterone system not recommended
- Potassium-sparing diuretics may increase serum potassium level
- Risk of renal impairment increased with NSAIDs
- Increased risk of lithium toxicity with lithium use
Contraindications
- Hypersensitivity to any component
- History of angioedema related to previous ACE inhibitor or ARB therapy
- Concomitant use of ACE inhibitors or aliskiren in diabetes patients
Side Effects
- Angioedema
- Hypotension
- Impaired Renal Function
- Hyperkalemia
- Cough
- Dizziness
Pregnancy and Lactation
- Safety and effectiveness not established in pediatric patients less than 1 year
- No relevant pharmacokinetic differences in elderly patients
- No dose adjustment required in mild hepatic impairment
- Not recommended in severe hepatic impairment
Precautions and Warnings
- May cause angioedema in certain patients
- May lower blood pressure and cause symptomatic hypotension
- Monitor serum potassium periodically and treat appropriately
Use in Special Populations
- Safety and effectiveness not established in pediatric patients
- No relevant pharmacokinetic differences in elderly patients
- Starting dose adjustment for severe renal or hepatic impairment
Overdose Effects
- Hypotension likely result of overdosage
- Symptomatic treatment recommended
- Unlikely to be removed by hemodialysis due to high protein binding
Storage Conditions
- Store in a dry place
- Keep below 30°C
- Protect from moisture
- Keep out of the reach of children