Entrovas 24 mg+26 mg (Tablet)

Unit Price: ৳ 45.00 (2 x 10: ৳ 900.00)
Strip Price: ৳ 450.00

Medicine Details

Categories

  • Cardiovascular Health
  • Pediatric Medicine

Indications

  • Reduction of cardiovascular death risk
  • Reduction of hospitalization risk for heart failure
  • Treatment of symptomatic heart failure in pediatric patients

Mode of Action

  • Contains neprilysin inhibitor, sacubitril
  • Contains angiotensin receptor blocker, valsartan
  • Inhibits neprilysin via LBQ657
  • Blocks angiotensin II type-1 receptor via valsartan

Dosage and Administration

  • Starting dose of 49/51 mg orally twice daily for adults
  • Starting dose varies for pediatric patients based on weight
  • Titration of dose for pediatric patients
  • Adjustment of dose for patients with renal or hepatic impairment

Interaction

  • Dual blockade of renin-angiotensin-aldosterone system not recommended
  • Potassium-sparing diuretics may increase serum potassium level
  • Risk of renal impairment increased with NSAIDs
  • Increased risk of lithium toxicity with lithium use

Contraindications

  • Hypersensitivity to any component
  • History of angioedema related to previous ACE inhibitor or ARB therapy
  • Concomitant use of ACE inhibitors or aliskiren in diabetes patients

Side Effects

  • Angioedema
  • Hypotension
  • Impaired Renal Function
  • Hyperkalemia
  • Cough
  • Dizziness

Pregnancy and Lactation

  • Safety and effectiveness not established in pediatric patients less than 1 year
  • No relevant pharmacokinetic differences in elderly patients
  • No dose adjustment required in mild hepatic impairment
  • Not recommended in severe hepatic impairment

Precautions and Warnings

  • May cause angioedema in certain patients
  • May lower blood pressure and cause symptomatic hypotension
  • Monitor serum potassium periodically and treat appropriately

Use in Special Populations

  • Safety and effectiveness not established in pediatric patients
  • No relevant pharmacokinetic differences in elderly patients
  • Starting dose adjustment for severe renal or hepatic impairment

Overdose Effects

  • Hypotension likely result of overdosage
  • Symptomatic treatment recommended
  • Unlikely to be removed by hemodialysis due to high protein binding

Storage Conditions

  • Store in a dry place
  • Keep below 30°C
  • Protect from moisture
  • Keep out of the reach of children

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