Apemeg 160 mg (Tablet)
Unit Price: ৳ 75.00 (2 x 6: ৳ 900.00)
Strip Price: ৳ 450.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Megestrol acetate |
| Company | Renata limited |
Title and Categories
- Apemeg Tablet
- Medicine
- Healthcare Product
- Antineoplastic Drug
Dimensions
N/A
Color Options
N/A
Functions
- Palliative treatment of advanced carcinoma of the breast
- Palliative treatment of advanced carcinoma of the endometrium
- Treatment of anorexia
- Treatment of cachexia
- Treatment of significant weight loss in AIDS patients
- Inhibition of pituitary gonadotrophin production
- Decrease in estrogen secretion
- Modifying and abolishing the stimulatory effects of estrogen on cells
Materials
- Megestrol Acetate
Technical Specifications
- Plasma half-life: 33-38 hours
- Peak plasma concentrations: 2-3 hours after a single oral dose
- Approximately 66% of the administered dose is excreted in the urine
- Approximately 20% of the administered dose is excreted in the feces
Design Elements
N/A
Usability Features
- Oral Suspension available
- Tablet form available
- Dosage as per indication - 160mg/day for breast cancer, 40-320mg/day for endometrial carcinoma, 800mg/day for oral suspension
Mode of Action
- Synthetic antineoplastic and progestational drug
- Mechanism of action against endometrial carcinoma not fully understood
- Decreases the number of hormone-dependent human breast cancer cells
- Modifies and abolishes the stimulatory effects of estrogen on breast cancer cells
Interaction
- Possible interactions with concomitant medications not investigated
- Estrogens and Progestogens may cause fluid retention
Contraindications
- History of hypersensitivity to Megestrol Acetate
- Known or suspected pregnancy
Indications
- Palliative treatment of advanced carcinoma of the breast
- Palliative treatment of advanced carcinoma of the endometrium
- Treatment of anorexia
- Treatment of cachexia
- Treatment of significant weight loss in AIDS patients
Dosage and Administration
- Tablet: 160mg/day for breast cancer
- Tablet: 40-320mg/day for endometrial carcinoma
- At least 2 months of continuous treatment recommended for determining efficacy
- Oral Suspension: Initial dosage 800mg/day (20ml/day)
Side Effects
- Weight gain
- Thromboembolic phenomena
- Glucocorticoid effects
- Nausea
- Dyspnea
- Tumor flare
- Hyperglycemia
- Glucose intolerance
- Alopecia
- Hypertension
- Carpal tunnel syndrome
- Mood changes
- Hot flashes
- Malaise
- Asthenia
- Lethargy
- Sweating
- Rash
Pregnancy and Lactation
- Pregnancy Category D
- Not recommended during the first four months of pregnancy
- Very small amounts excreted in mother's milk
- Potential adverse effects on the newborn
- Nursing should be discontinued during treatment
Precautions and Warnings
- Close surveillance for patients treated for recurrent or metastatic cancer
- Use with caution in patients with a history of thromboembolic disease
- Exacerbation of preexisting diabetes reported
Use in Special Populations
- Pediatric Use: Safety and effectiveness not established
- Geriatric Use: Insufficient data for patients 65 years and older
Overdose Effects
- No serious unexpected side effects from studies involving dosages up to 1600mg/day
Storage Conditions
- Store in a cool, dry place below 30°C
- Keep away from light and moisture
- Keep out of reach of children