Intrax 500 mg/5 ml (IM/IV Injection)
5 ml ampoule: ৳ 50.00 (1 x 5: ৳ 250.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Tranexamic acid |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Prophylaxis and therapy of hemophtoes
- Digestive hemorrhages
- Hemorrhagic syndromes in leukaemia
- Cirrhosis and hemophilia
- Thrombocytopenic purpura
- Accidents during thrombolytic therapy and transfusion
Pharmacology
- Preparation of tranexamic acid
- Antifibrinolytic action
- Inhibition of plasminogen activation
- Low acute and chronic toxicity
- Well absorbed by oral route
Dosage & Administration
- Usual dose for adults: 500-1000 mg 3 times daily
- Prophylactic doses: 0.5-1 gm orally, 500 mg by parenteral route
- Therapeutic doses: 1-3 gm orally in divided doses
- Pediatric dosage guidelines
Interaction
- Incompatibility with penicillins
- Antagonism with thrombolytic drugs
- Potential for increased thrombus formation with estrogen containing drugs
- Avoid direct admixture with whole blood during transfusion
Contraindications
- Known individual hypersensitivity to the product
- Thromboembolic disease
- Arterial and venous thrombosis
- Endocavitary hemorrhages
- Serious kidney failure
Side Effects
- Infrequent cases of sense of fatigue
- Conjunctival irritation
- Nasal blockage
- Itching
- Skin reddening
- Exanthems
- Nausea
- Diarrhea
- Gastric pyrosis
- Postural hypotension
Pregnancy & Lactation
- Avoid administration during known and presumed pregnancy
- Passage into breast milk
- Unlikely antifibrinolytic effect in the infant
Precautions & Warnings
- Use in hyperfibrinolysis cases
- Prolonged therapy of hemorrhages
- Dose reduction in hematuria
- Caution in renal insufficiency or anuric syndromes
- Particular care in cardiopathic and hepatopathic subjects
Therapeutic Class
- Anti-fibrinolytic drugs
- Haemostatic drugs
Storage Conditions
- Store in dry place at 15-30°C
- Away from light
- Keep out of children's reach