Redimat 2 mg+500 mg (Tablet (Extended Release))

Unit Price: ৳ 10.00 (30's pack: ৳ 300.00)

Medicine Details

Category Details
Generic Glimepiride metformin
Company Radius pharmaceuticals ltd

Indications

  • Adjunct to diet and exercise in type 2 diabetes mellitus patients
  • Monotherapy with glimepiride or metformin
  • Replacement of combination therapy of glimepiride and metformin

Pharmacology

  • Decreases blood glucose concentration
  • Stimulates the release of insulin from pancreatic beta cells
  • Reduces basal hepatic glucose production
  • Increases peripheral tissue sensitivity to insulin
  • Improves insulin sensitivity by increasing peripheral glucose uptake
  • Hypoglycaemic action persists for 24 hours

Dosage

  • Governed by desired blood glucose level
  • Lowest dosage sufficient for desired metabolic control
  • Regular measurement of glucose levels in blood and urine
  • Maximum recommended dose per day: 8 mg of glimepiride and 2000 mg of metformin

Administration

  • Must be swallowed whole and not crushed or chewed

Interaction

  • Metabolized by cytochrome P450 2C9 (CYP2C9)
  • Potentiation of blood-glucose-lowering effect
  • Weakening of blood-glucose-lowering effect
  • May lead to hypoglycaemia or raised blood glucose levels
  • Alcohol intake may potentiate or weaken blood-glucose-lowering action
  • Bile acid sequestrant reduces glimepiride absorption

Contraindications

  • Hypersensitivity to glimepiride, metformin, or sulfonylureas
  • Pregnancy and breastfeeding
  • Severe impairment of liver function
  • Severe renal failure or dysfunction
  • Acute metabolic acidosis
  • Tissue hypoxia conditions
  • Acute alcohol intoxication

Side Effects

  • Hypoglycaemia
  • Temporary visual impairment
  • Gastrointestinal symptoms
  • Hepatitis, elevation of liver enzyme levels
  • Alopecia
  • Allergic or pseudo allergic reactions
  • Weight gain
  • Nausea, vomiting, diarrhoea, abdominal pain

Pregnancy & Lactation

  • Glimepiride must not be taken during pregnancy
  • Metformin should not be used during pregnancy
  • Glimepiride must not be taken by breastfeeding women

Precautions & Warnings

  • Risk of hypoglycaemia in initial weeks of treatment
  • Increased risk of hypoglycaemia if risk factors are present
  • Caution in G6PD-deficient patients
  • Monitoring of thyroid-stimulating hormone (TSH) levels in patients with hypothyroidism
  • Long-term treatment associated with decrease in vitamin B12 serum levels

Use in Special Populations

  • Data insufficient to recommend pediatric use
  • Renal impairment assessment before initiation of treatment
  • Maximum daily dose based on GFR levels

Overdose Effects

  • Acute overdosage may lead to severe life-threatening hypoglycaemia
  • Hypoglycaemia has not been seen with metformin doses of up to 85 g
  • Lactic acidosis is a medical emergency and must be treated in hospital

Therapeutic Class

Combination Oral hypoglycemic preparations

Storage Conditions

Store in a cool and dry place, protected from light

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