Tracid 500 mg (Tablet)
Unit Price: ৳ 23.40 (2 x 10: ৳ 468.00)
Strip Price: ৳ 234.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Tranexamic acid |
| Company | Acme laboratories ltd |
| Also available as |
Indications
- Prophylaxis and therapy of hemoptysis
- Digestive hemorrhages
- Hemorrhagic syndromes in leukaemia
- Cirrhosis and hemophilia
- Thrombocytopenic purpura
- Accidents during thrombolytic therapy and transfusion
- Prophylaxis and antihemorrhagic therapy during operations
- Prophylaxis and antihemorrhagic therapy of prostatic, vesical and renal surgery
- Prophylaxis and therapy of post-partum and puerperium hemorrhages
- Hemorrhagic metropathies
- Functional menometrorrhagias
- Idiopathic or IUD(lntra uterine Device) induced menorrhagias
- Prophylaxis and antihemorrhagic therapy during tonsillectomy
- Epistaxis
- Prophylaxis and antihemorrhagic therapy during maxillofacial operations
- Tooth extractions
- To promote the formation of a fibrin capsule to wall off and inhibit the growth of ovarian tumors
- To cause regression of ascites secondary to carcinoma
- To reduce bleeding during surgical interventions
Pharmacology
- Tranexamic acid (trans-4 aminomethyl-cyclohexanecarboxylic acid)
- Strong antifibrinolytic action
- Inhibition of plasminogen activation
- Well absorbed by oral route
- Effect seen 15-30 minutes after administration
- Excreted mainly by renal route
- Low acute and chronic toxicity
- No interference with clotting processes
- No tendency to thrombophilia
Dosage & Administration
- Usual dose for adults: 500-1000 mg 3 times daily
- Mean recommended daily doses for prophylaxis: 0.5-1 gm orally, 500 mg by the parenteral route
- Therapy of hemorrhagic manifestations: oral dose increases to 1-3 gm given in divided doses
- Usual dose for children for prophylaxis: 5-10 mg per kg of body weight orally daily in divided doses
- For therapeutic purposes in children: Oral doses are doubled, intravenous and intramuscular treatment initiated with 10 mg/kg
Interaction
- Incompatible with solutions containing penicillins
- Thrombolytic drugs like Streptokinase & Urokinase antagonize the antifibrinolytic action
- Increased potential for thrombus formation with concomitant administration of estrogen containing drugs
- Direct admixture with whole blood to be avoided during transfusion
Contraindications
- Known individual hypersensitivity to the product
- Thromboembolic disease
- Arterial and venous thrombosis
- Endocavitary hemorrhages
- Serious kidney failure
Side Effects
- Infrequent cases of sense of fatigue
- Conjunctival irritation
- Nasal blockage
- Itching
- Skin reddening
- Exanthems
- Nausea
- Diarrhea
- Gastric pyrosis
- Rare cases of postural hypotension
Pregnancy & Lactation
- Tranexamic Acid should not be administered during known and presumed pregnancy
- Passes into breast milk to a concentration of approximately one hundredth of the concentration in the maternal blood
Precautions & Warnings
- Use in cases where there is hyperfibrinolysis
- Prophylactic treatment to begin 24 hours before the operation
- Therapy of hemorrhages to be prolonged for at least 24 hours after manifestations have disappeared
- Reduce doses in cases of isolated hematuria
- Avoid use in serious renal insufficiency or anuric syndromes
- Particular care required in cardiopathic and hepatopathic subjects
Therapeutic Class
- Anti-fibrinolytic drugs
- Haemostatic drugs
Storage Conditions
- Store in a dry place at 15-30°C
- Away from light
- Keep out of children's reach