Restobac 5 mg (Tablet)

Unit Price: ৳ 5.50 (3 x 10: ৳ 165.00)
Strip Price: ৳ 55.00

Medicine Details

Category Details
Generic Baclofen
Company General pharmaceuticals ltd
Also available as
Restobac 10 mg tablet Restobac 25 mg tablet

Indications

  • Spasticity resulting from multiple sclerosis
  • Flexor spasms and concomitant pain
  • Clonus and muscular rigidity
  • Skeletal muscle spasm resulting from rheumatic disorders
  • Spinal cord injuries and other spinal cord diseases
  • Cerebrovascular accidents or neoplastic or degenerative brain disease

Pharmacology

Inhibition of monosynaptic and polysynaptic reflexes by stimulating GABA receptors, CNS depression, antinociceptive effect

Dosage & Administration

  • Adult & children over 10 years: 5 mg 3 times daily, preferably with or after food, gradually increased; max. 100 mg daily
  • Children <10 years: Treatment usually started with 2.5 mg (2.5 ml) given 4 times daily then raised according to requirement

Interactions

  • Increased sedation with agents acting on the central nervous system
  • Increase in fall in blood pressure when combined with antihypertensives
  • Potentiated pharmacological effects when combined with tricyclic antidepressants
  • Reports of mental confusion, hallucinations, headaches, nausea and agitation with Parkinson's treatment
  • Increased CNS depressant effects with MAO inhibitors
  • Possible synergistic effect with magnesium sulphate or other neuromuscular blocking agents

Contraindications

Hypersensitivity to any component of this product

Side Effects

  • Central Nervous System:
    • Transient drowsiness
    • Daytime sedation
    • Dizziness
    • Weakness
    • Fatigue
    • Headache
    • Insomnia
    • Euphoria
    • Excitement
    • Depression
    • Confusion
    • Hallucinations
    • Paraesthesia
    • Nightmares
    • Muscle pain
    • Tinnitus
    • Slurred speech
    • Co-ordination disorder
    • Tremor
    • Rigidity
    • Dystonia
    • Ataxia
    • Blurred vision
    • Nystagmus
    • Strabismus
    • Miosis
    • Mydriasis
    • Diplopia
    • Dysarthria
    • Epileptic seizures
    • Respiratory depression
  • Cardiovascular:
    • Hypotension
    • Instances of dyspnoea
    • Palpitation
    • Chest pain
    • Syncope
  • Gastrointestinal:
    • Nausea
    • Constipation
    • Dry mouth
    • Anorexia
    • Taste disorder
    • Abdominal pain
    • Vomiting
    • Diarrhoea
    • Positive test for occult blood in stool
  • Genitourinary:
    • Urinary frequency
    • Enuresis
    • Urinary retention
    • Dysuria
    • Impotence
    • Inability to ejaculate
    • Nocturia
    • Haematuria
  • Other:
    • Rash
    • Pruritus
    • Ankle oedema
    • Excessive perspiration
    • Weight gain
    • Nasal congestion
    • Visual disturbances
    • Hepatic function disorders
    • Paradoxical increase in spasticity

Pregnancy & Lactation

  • Category: B3
  • Use during pregnancy: Safe use not established, crosses placental barrier
  • Use during lactation: Excreted in breast milk in small quantities

Precautions & Warnings

  • Lower doses for impaired renal function
  • Cautious treatment for patients with psychotic disorders, schizophrenia, depressive or manic disorders
  • Possible lowering of the convulsion threshold in patients with epilepsy
  • Use with caution in patients with peptic ulcers, cerebrovascular diseases, or hepatic, renal or respiratory failure
  • Careful monitoring of respiratory and cardiovascular function
  • Potential improvement of neurogenic disturbances affecting emptying of the bladder
  • Poor tolerance by stroke patients
  • Regular laboratory tests for patients with hepatic diseases or diabetes mellitus

Overdose Effects

Gastric lavage important in case of severe overdose

Therapeutic Class

Centrally acting Skeletal Muscle Relaxants

Storage Conditions

Keep below 30°C temperature, away from light & moisture, Keep out of reach of children

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