Empadus M 5 mg+500 mg (Tablet)
Unit Price: ৳ 20.00 (3 x 10: ৳ 600.00)
Strip Price: ৳ 200.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Empagliflozin metformin hydrochloride |
| Company | Opsonin pharma ltd |
Indications
- Treatment of adults with type 2 diabetes mellitus
- Adjunct to diet and exercise
- Insufficiently controlled on maximally tolerated dose of Metformin alone
- Combination with other medicinal products for diabetes
- Already being treated with combination of Empagliflozin and Metformin as separate tablets
Pharmacology
- Inhibitor of Sodium-Glucose Co-Transporter 2 (SGLT2)
- Reduces renal reabsorption of filtered glucose
- Lowers renal threshold for glucose
- Increases urinary glucose excretion
- Biguanide type oral antihyperglycemic drug
Dosage & Administration
- Individualized dosage based on effectiveness and tolerability
- Take twice daily with meals
- Dose escalation should be gradual
- Maximum recommended daily dose of Metformin Hydrochloride is 2000 mg and Empagliflozin is 25 mg
Interaction
- Diuretics
- Insulin or Insulin Secretagogues
- Positive Urine Glucose Test
- Drugs that Reduce Metformin Clearance
- Carbonic Anhydrase Inhibitors
- Drugs Affecting Glycemic Control
- Alcohol
Contraindications
- Hypersensitivity to Empagliflozin and Metformin
- Acute metabolic acidosis
- Diabetic pre-coma
- Severe renal failure
- Acute conditions altering renal function
- Diseases causing tissue hypoxia
- Hepatic impairment
- Acute alcohol intoxication
Side Effects
- Urinary tract infection
- Female genital mycotic infections
- Diarrhea
- Nausea/vomiting
- Flatulence
- Abdominal discomfort
- Indigestion
- Asthenia
- Headache
- Hypoglycemia
- Vaginal moniliasis
- Urosepsis
- Thirst
- Taste disturbance
- Pruritus
- Increased urination
- Serum lipids increased
- Urticaria
- Dysuria
- Blood creatinine increased
- Lactic acidosis
Pregnancy & Lactation
- Potential risk to fetus
- Not recommended during breastfeeding
Precautions & Warnings
- Lactic Acidosis
- Hypotension
- Ketoacidosis
- Acute kidney injury & impairment in renal function
- Urosepsis, Pyelonephritis, Fournier's gangrene & Genital mycotic infections
- Hypoglycemia
- Vitamin B12 Deficiency
- Increased LDL-C
- Macrovascular Outcomes
Overdose Effects
- No toxicity observed with single doses of Empagliflozin up to 800 mg
- No hypoglycemia seen with Metformin doses up to 85 g
- Lactic acidosis is a medical emergency
Therapeutic Class
- Combination Oral hypoglycemic preparations
Storage Conditions
- Keep below 30°C
- Protected from light & moisture
- Keep out of the reach of children