Tramic 500 mg (Capsule)

Title

• Tramic

Categories

• Medicine
• Pharmaceutical

Description

• Antifibrinolytic medication for prophylaxis and therapy of various hemorrhagic disorders
• Preparation of tranexamic acid with strong antifibrinolytic action
• Low acute and chronic toxicity with well-absorbed oral route

Functions

• Prophylaxis and therapy of hemoptysis
• Treatment of digestive hemorrhages
• Management of hemorrhagic syndromes in various medical conditions
• Antihemorrhagic therapy during different types of surgery
• Prophylaxis of urological hemorrhagic conditions
• Management of post-partum and puerperium hemorrhages
• Therapy for hemorrhagic metropathies and menometrorrhagias
• Antihemorrhagic therapy during tonsillectomy and other otorhinolaryngological procedures
• Prophylaxis and therapy of hemorrhages in oncology as supportive therapy
• Promotion of fibrin capsule formation for ovarian tumor inhibition
• Reduction of bleeding during surgical interventions

Materials

• Tranexamic acid (trans-4 aminomethyl-cyclohexanecarboxylic acid)

TechnicalSpecifications

• 10 times more active than conventional hemostatics
• Inhibition of plasminogen activation
• Low acute toxicity
• Well absorbed by oral route
• Excreted mainly by renal route
• No interference with clotting processes
• Incompatibility with penicillins and thrombolytic drugs
• Passage into breast milk at low concentration

DosageAndAdministration

• Usual dose for adults: 500-1000 mg 3 times daily
• Prophylactic dose for children: 5-10 mg per kg of body weight daily
• Therapeutic dose for children: 10-20 mg per kg of body weight
• No reduction in dosage for elderly unless evidence of renal failure

Interactions

• Incompatibility with solutions containing penicillins
• Antagonism with thrombolytic drugs
• Increased potential for thrombus formation with estrogen-containing drugs
• Avoid direct admixture with whole blood during transfusion

Contraindications

• Known individual hypersensitivity
• Thromboembolic disease
• Arterial and venous thrombosis
• Endocavitary hemorrhages
• Serious kidney failure

SideEffects

• Sense of fatigue
• Conjunctival irritation
• Nasal blockage
• Itching
• Skin reddening
• Exanthems
• Nausea
• Diarrhea
• Gastric pyrosis
• Rare cases of postural hypotension
• Hypersensitivity reactions

PregnancyAndLactation

• Avoid during known and presumed pregnancy
• Passage into breast milk at low concentration with unlikely antifibrinolytic effect in infants

PrecautionsAndWarnings

• Use in cases of hyperfibrinolysis
• Initiate prophylactic treatment 24 hours before operation
• Prolong therapy of hemorrhages for at least 24 hours after disappearance of manifestations
• Reduce doses in hematuria to prevent formation of clots in urinary tract
• Avoid use in serious renal insufficiency or anuric syndromes
• Use with caution in less serious renal dysfunctions
• Exercise particular care in cardiopathic and hepatopathic subjects

TherapeuticClass

• Anti-fibrinolytic drugs
• Haemostatic drugs

StorageConditions

• Store in a dry place at 15-30°C
• Away from light
• Keep out of children's reach

Related Brands

• Tranexil 500 mg/5 ml (IM/IV Injection) - beximco-pharmaceuticals-ltd
• Traxyl 500 mg (Capsule) - nuvista-pharma-ltd
• Trexam 500 mg (Tablet) - healthcare-pharmaceuticals-ltd
• Trexam 500 mg/5 ml (IM/IV Injection) - healthcare-pharmaceuticals-ltd
• Xamic 500 mg (Capsule) - renata-limited